Evidence map›Paper›PMID 36711798›Full record

ArticlebioRxiv : the preprint server for biology2023

Dynamic Effects of Ventral Hippocampal NRG3/ERBB4 Signaling on Nicotine Withdrawal-Induced Responses.

Miranda L Fisher, Emily R Prantzalos, Bernadette O'Donovan, Tanner Anderson, Pabitra K Sahoo, Jeffery L Twiss, Pavel I Ortinski, Jill R Turner

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Miranda L FisherDepartment of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
Emily R PrantzalosDepartment of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
Bernadette O'DonovanDepartment of Anesthesiology, Duke University School of Medicine, Durham, North Carolina, USA.
Tanner AndersonDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Pabitra K SahooDepartment of Biological Sciences, University of South Carolina College of Arts and Sciences, Columbia, South Carolina, USA.
Jeffery L TwissDepartment of Biological Sciences, University of South Carolina College of Arts and Sciences, Columbia, South Carolina, USA.
Pavel I OrtinskiDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Jill R TurnerDepartment of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
University of Kentucky · USUniversity of South Carolina · USDuke University · US

Funding

Research Training in Drug Abuse BehaviorT32DA035200 · NIDA · UNIVERSITY OF KENTUCKY · PI CRAIG R RUSH, William Walton Stoops · 2013 to 2026
$4.4M
Functional and Genomic Signatures of Escalated Fentanyl UseR01DA053070 · NIDA · UNIVERSITY OF KENTUCKY · PI BARDO, MICHAEL T, ORTINSKI, PAVEL IVANOVICH · 2021 to 2025
$3.2M
Dynamic Signaling of NRG3-ErbB4 in the Hippocampus Mediates Nicotine Withdrawal PhenotypesR01DA044311 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TURNER, JILL R. · 2018 to 2022
$1.9M
Neural microcircuit selection by astrocyte signaling following cocaine exposureR01DA041513 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ORTINSKI, PAVEL IVANOVICH · 2017 to 2021
$1.6M
NIDA NIH HHS R01 DA041513NIDA NIH HHS R01 DA044311NIDA NIH HHS R01 DA053070NIDA NIH HHS T32 DA035200
6 · The paper itself

Abstract

Tobacco smoking remains a leading cause of preventable death in the United States, with a less than 5% success rate for smokers attempting to quit. High relapse rates have been linked to several genetic factors, indicating that the mechanistic relationship between genes and drugs of abuse is a valuable avenue for the development of novel smoking cessation therapies. For example, various single nucleotide polymorphisms (SNPs) in the gene for neuregulin 3 (

Identifiers

PMID36711798
PMCPMC9882308
OpenAlexW4317603966

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.