Evidence map›Paper›PMID 36711807›Full record

ArticleResearch square2023

Post-fast refeeding enhances intestinal stem cell-mediated regeneration and tumourigenesis through mTORC1-dependent polyamine synthesis.

Shinya Imada, Heaji Shin, Saleh Khawaled, Sven W Meckelmann, Charles A Whittaker, Renan Oliveira Corrêa, Dikshant Pradhan, Gizem Calibasi-Kocal, Luiza Martins Nascentes Melo, Gabriele Allies and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Fasting the Stem Cells to Boost their Metabolic Functions.Current stem cell research & therapy · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 4 countries.

Shinya ImadaDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.
Heaji ShinDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.
Saleh KhawaledDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.
Sven W MeckelmannApplied Analytical Chemistry, University of Duisburg-Essen, 45141 Essen, Germany.
Charles A WhittakerBarbara K. Ostrom (1978) Bioinformatics and Computing Core Facility, Swanson Biotechnology Center, Koch Institute at the MIT, Cambridge, MA 02139, USA.
Renan Oliveira CorrêaDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.
Dikshant PradhanBarbara K. Ostrom (1978) Bioinformatics and Computing Core Facility, Swanson Biotechnology Center, Koch Institute at the MIT, Cambridge, MA 02139, USA.
Gizem Calibasi-KocalDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.
Luiza Martins Nascentes MeloDepartment of Dermatology, University Hospital Essen & German Cancer Consortium, Partner Site, Essen, 45147, Germany.
Gabriele AlliesDepartment of Dermatology, University Hospital Essen & German Cancer Consortium, Partner Site, Essen, 45147, Germany.
Pia WittenhoferApplied Analytical Chemistry, University of Duisburg-Essen, 45141 Essen, Germany.
Oliver J SchmitzApplied Analytical Chemistry, University of Duisburg-Essen, 45141 Essen, Germany.ORCID 0000-0003-2184-1207
Jatin RoperDivision of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, NC 27710, USA.
Marco Aurelio Ramirez VinoloLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP 13083-862, Brazil.
Chia-Wei ChengDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.
Alpaslan TasdoganDepartment of Dermatology, University Hospital Essen & German Cancer Consortium, Partner Site, Essen, 45147, Germany.
Ömer H YilmazDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-7577-4612
University of Duisburg-Essen · DEEssen University Hospital · DEMassachusetts Institute of Technology · USColumbia University · USDuke University · USInstitut des Maladies Génétiques Imagine · FRStanford University · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Understanding and Improving Platinum Anticancer DrugsR01CA034992 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 1985 to 2018
$6.8M
Project 2U54CA224068 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CORCORAN, RYAN BRUCE, FLAHERTY, KEITH T · 2017 to 2021
$6.3M
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.R01CA257523 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, STAPPENBECK, THADDEUS S · 2021 to 2025
$3.7M
Mechanisms of HIV-associated epithelialintestinal stem cell (ISC) dysfunctionR01DK126545 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KLOVERPRIS, HENRIK, KWON, DOUGLAS · 2020 to 2024
$3.6M
Dietary control of stem cells in physiology and cancerR01CA211184 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2017 to 2021
$2.0M
MICROBIOTA-DEPENDENT CONTROL OF CLOSTRIDIUM DIFFICILE: THE ROLE OF ACETATE AND IL-22 BINDING PROTEINR01DK126969 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2021 to 2024
$1.6M
Elucidating the role of fasting in intestinal stemness and tissue regenerationR00DK123407 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHENG, CHIA-WEI · 2021 to 2023
$727k
NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA034992NCI NIH HHS R01 CA211184NCI NIH HHS R01 CA257523NCI NIH HHS U54 CA224068NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R00 DK123407NIDDK NIH HHS R01 DK126545NIDDK NIH HHS R01 DK126969
6 · The paper itself

Abstract

For more than a century, fasting regimens have improved health, lifespan, and tissue regeneration in diverse organisms, including humans. However, how fasting and post-fast refeeding impact adult stem cells and tumour formation has yet to be explored in depth. Here, we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation: Post-fast refeeding augments the regenerative capacity of

Identifiers

PMID36711807
PMCPMC9882602
OpenAlexW4315434079

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.