Evidence map›Paper›PMID 36711878›Full record

ArticleResearch square2023

Localized cardiac metabolic trajectories and post-infectious metabolic sequelae in experimental Chagas disease.

Zongyuan Liu, Rebecca Ulrich, April L Kendricks, Kate Wheeler, Ana Carolina Leão, Jeroen Pollet, Maria Elena Bottazzi, Peter Hotez, Fabian Gusovsky, Kathryn M Jones and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Zongyuan LiuDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America.
Rebecca UlrichLaboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, Oklahoma, United States of America.
April L KendricksSouthern Star Medical Research Institute, Houston, TX, United States of America.
Kate WheelerDepartment of Biology, University of Oklahoma, Norman, Oklahoma, United States of America.
Ana Carolina LeãoDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, United States of America.
Jeroen PolletDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, United States of America.ORCID 0000-0003-1420-4015
Maria Elena BottazziDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, United States of America.ORCID 0000-0002-8429-0476
Peter HotezDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, United States of America.
Fabian GusovskyGlobal Health Research, Eisai, Inc., Cambridge, MA, USA.
Kathryn M JonesDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, United States of America.ORCID 0000-0001-8745-1987
Laura-Isobel McCallDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
UM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 1994 to 2015
$21.7M
METABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6M
Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection.R01AI168038 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Kathryn Marie Jones · 2022 to 2026
$3.8M
UC San Diego RAPID Faculty Development Program in Infectious DiseasesR25AI147376 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADRIANA H TREMOULET, Joann Trejo · 2020 to 2026
$2.5M
Small molecule biomarkers of cardiac Chagas disease progressionR21AI156669 · NIAID · UNIVERSITY OF OKLAHOMA · PI BOWMAN, NATALIE MCCARTER, GILMAN, ROBERT H · 2021 to 2022
$458k
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NHGRI NIH HHS UM1 HG006348NIAID NIH HHS P30 AI036211NIAID NIH HHS R01 AI168038NIAID NIH HHS R21 AI156669NIAID NIH HHS R25 AI147376NIDDK NIH HHS R01 DK114356
6 · The paper itself

Abstract

Post-infectious conditions, where clinical symptoms fail to resolve even after pathogen clearance, present major health burdens. However, the mechanisms involved remain poorly understood. In Chagas disease (CD), caused by the parasite

Identifiers

PMID36711878
PMCPMC9882638

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.