Evidence map›Paper›PMID 36711928›Full record

ArticleResearch square2023

Thiol catalyzed formation of NO-ferroheme regulates canonical intravascular NO signaling.

Anthony W DeMartino, Laxman Poudel, Matthew R Dent, Xiukai Chen, Qinzi Xu, Brendan S Gladwin, Jesús Tejero, Swati Basu, Elmira Alipour, Yiyang Jiang and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Anthony W DeMartinoDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-5303-5758
Laxman PoudelDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.
Matthew R DentHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Xiukai ChenHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Qinzi XuHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Brendan S GladwinHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jesús TejeroHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-3245-9978
Swati BasuDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.
Elmira AlipourDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.
Yiyang JiangDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.
Jason J RoseDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mark T GladwinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Daniel B Kim-ShapiroDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.
Wake Forest University · USUniversity of Maryland, Baltimore · USUniversity of Pittsburgh · US

Funding

Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide HomeostasisR01HL098032 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin · 2009 to 2026
$12.5M
Antidote for inhaled CO poisoning based on mutationally engineered neuroglobinR01HL125886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin, Jesus Tejero Bravo · 2015 to 2026
$7.9M
Discovering and Developing Recombinant Molecular Scavenging Agents for the Treatment of Carbon Monoxide Induced Cardiovascular DysfunctionK08HL136857 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSE, JASON J · 2018 to 2022
$970k
NHLBI NIH HHS K08 HL136857NHLBI NIH HHS R01 HL098032NHLBI NIH HHS R01 HL125886
6 · The paper itself

Abstract

Nitric oxide (NO) is an endogenously produced physiological signaling molecule that regulates blood flow and platelet activation. However, both the intracellular and intravascular diffusion of NO is severely limited by scavenging reactions with hemoglobin, myoglobin, and other hemoproteins, raising unanswered questions as to how free NO can signal in hemoprotein-rich environments, like blood and cardiomyocytes. We explored the hypothesis that NO could be stabilized as a ferrous heme-nitrosyl complex (Fe

Identifiers

PMID36711928
PMCPMC9882697
OpenAlexW4317609822

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.