Evidence map›Paper›PMID 36712113›Full record

ArticlebioRxiv : the preprint server for biology2023

A single amino acid polymorphism in natural Metchnikowin alleles of

Jessamyn I Perlmutter, Joanne R Chapman, Mason C Wilkinson, Isaac Nevarez-Saenz, Robert L Unckless

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jessamyn I PerlmutterDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Joanne R ChapmanInstitute of Environmental and Scientific Research (ESR), Christchurch, New Zealand.
Mason C WilkinsonDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.
Isaac Nevarez-SaenzDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Robert L UncklessDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
University of Kansas · USNew Zealand Institute for Public Health and Forensic Science · NZVanderbilt University · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Protein Structure Laboratory P30GM110761 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2014 to 2018
$5.6M
The causes of balancing selection on immunity genes: from populations to molecular interactions.R01AI139154 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI UNCKLESS, ROBERT L · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI139154NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P30 GM110761
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are at the interface of interactions between hosts and microbes and are therefore expected to be fast evolving in a coevolutionary arms race with pathogens. In contrast, previous work demonstrated that one AMP, Metchikowin (Mtk), has a single residue that segregates as either proline (P) or arginine (R) in populations of four different

Identifiers

PMID36712113
PMCPMC9882182
OpenAlexW4317497258

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.