Evidence map›Paper›PMID 36712192›Full record

ArticleJournal of medical and biological engineering2022

Three-Dimensional Ultrasound Localization Microscopy with Bipartite Graph-Based Microbubble Pairing and Kalman-Filtering-Based Tracking on a 256-Channel Verasonics Ultrasound System with a 32 × 32 Matrix Array.

U-Wai Lok, Chengwu Huang, Joshua D Trzasko, Yohan Kim, Fabrice Lucien, Shanshan Tang, Ping Gong, Pengfei Song, Shigao Chen

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical and biological engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. High-Volume Acquisition Rate Nonlinear Imaging Enables Robust 3-D Ultrasound Localization Microscopy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025
    Article
  2. Advancements in Three-Dimensional Super-Resolution Ultrasound Imaging: A Narrative Review.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

U-Wai LokDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Chengwu HuangDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Joshua D TrzaskoDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Yohan KimDepartment of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Fabrice LucienDepartment of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Shanshan TangDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Ping GongDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Pengfei SongDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Shigao ChenDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Mayo Clinic · USUniversity of Illinois Urbana-Champaign · US

Funding

High-resolution High-speed Photoacoustic and Ultrasound Imaging of SmallVessel Functions in Ischemic StrokeR01NS111039 · NINDS · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2023
$2.7M
Next-Generation Ultrasound Localization MicroscopyR21EB030072 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SONG, PENGFEI · 2020 to 2022
$927k
NIBIB NIH HHS R21 EB030072NINDS NIH HHS R01 NS111039
6 · The paper itself

Abstract

Three-dimensional (3D) ultrasound localization microscopy (ULM) using a 2-D matrix probe and microbubbles (MBs) has been recently proposed to visualize microvasculature beyond the ultrasound diffraction limit in three spatial dimensions. However, 3D ULM suffers from several limitations: (1) high system complexity due to numerous channel counts, (2) complex MB flow dynamics in 3D, and (3) extremely long acquisition time. To reduce the system complexity while maintaining high image quality, we used a sub-aperture process to reduce received channel counts. To address the second issue, a 3D bipartite graph-based method with Kalman filtering-based tracking was used in this study for MB tracking. An MB separation approach was incorporated to separate high concentration MB data into multiple, sparser MB datasets, allowing better MB localization and tracking for a limited acquisition time. The proposed method was first validated in a flow channel phantom, showing improved spatial resolutions compared with the contrasted enhanced power Doppler image. Then the proposed method was evaluated with an

Identifiers

PMID36712192
PMCPMC9881453
OpenAlexW4307959260

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.