ReviewBiological psychiatry global open science2023
Neurite Orientation Dispersion and Density Imaging in Psychiatric Disorders: A Systematic Literature Review and a Technical Note.
Review in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bibliometric analysis of neurite orientation dispersion and density imaging: research patterns, evolution, and frontier.Frontiers in neuroscience · 2026Pooled it
- A systematic review and meta-analysis of neuroimaging studies examining synaptic density in individuals with psychotic spectrum disorders.BMC psychiatry · 2024Pooled it
- Cortical and subcortical microstructure integrity changes after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and relates to clinical outcomes.Addiction biology · 2024Trial
- Phenotype-specific white matter microstructural alterations and their clinical correlates in Wilson disease.Scientific reports · 2026Article
- Gene dosage effects of 22q11.2 copy number variants on in-vivo measures of white matter axonal density and dispersion.Molecular psychiatry · 2026Article
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Multimodal age-dependent diffusion-MRI analysis of the neocortex in a rat model of cortical dysplasia.Scientific reports · 2026Article
- Microstructural Alterations of the Corpus Callosum in Patients with First-Episode Schizophrenia Revealed by NODDI: Dissociation Between Neurite Density and Orientation Dispersion in the Splenium.Bioengineering (Basel, Switzerland) · 2026Article
- Deep Learning Empowered Microstructure Codebook: New Paradigm for Multi-Parameter Tissue Characterization Estimation.Human brain mapping · 2026Article
- Associations between cerebellum and major psychiatric disorders: a bidirectional Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Association of corpus callosum and corticospinal tract microstructure with bimanual coordination in children with unilateral cerebral palsy.Experimental brain research · 2026Article
- Motor learning induces myelin-related white matter changes revealed by MRI-based in vivo histology.Communications biology · 2026Article
- Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The structural grammar of integration and competition in the human connectome.Frontiers in computational neuroscience · 2026Article
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Research square · 2025Article
- Article
- Decreased hippocampal neurite density in late-middle-aged adults following prenatal exposure to higher levels of maternal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- In vivo mapping of infant brain microstructure with neurite orientation dispersion and density imaging.Brain structure & function · 2025Review
- Decreased hippocampal neurite density in late middle-aged adults following prenatal exposure to higher levels of maternal inflammation.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
While major psychiatric disorders lack signature diagnostic neuropathologies akin to dementias, classic postmortem studies have established microstructural involvement, i.e., cellular changes in neurons and glia, as a key pathophysiological finding. Advanced magnetic resonance imaging techniques allow mapping of cellular tissue architecture and microstructural abnormalities in vivo, which holds promise for advancing our understanding of the pathophysiology underlying psychiatric disorders. Here, we performed a systematic review of case-control studies using neurite orientation dispersion and density imaging (NODDI) to assess brain microstructure in psychiatric disorders and a selective review of technical considerations in NODDI. Of the 584 potentially relevant articles, 18 studies met the criteria to be included in this systematic review. We found a general theme of abnormal gray and white matter microstructure across the diagnostic spectrum. We also noted significant variability in patterns of neurite density and fiber orientation within and across diagnostic groups, as well as associations between brain microstructure and phenotypical variables. NODDI has been successfully used to detect subtle microstructure abnormalities in patients with psychiatric disorders. Given that NODDI indices may provide a more direct link to pathophysiological processes, this method may not only contribute to advancing our mechanistic understanding of disease processes, it may also be well positioned for next-generation biomarker development studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.