Evidence map›Paper›PMID 36713383›Full record

ArticleFrontiers in immunology2022

CK2β-regulated signaling controls B cell differentiation and function.

Laura Quotti Tubi, Elisa Mandato, Sara Canovas Nunes, Arash Arjomand, Fortunato Zaffino, Sabrina Manni, Alessandro Casellato, Paolo Macaccaro, Nicola Vitulo, Sara Zumerle and 15 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 3 countries.

Laura Quotti TubiDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Elisa MandatoDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Sara Canovas NunesDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Arash ArjomandDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Fortunato ZaffinoDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Sabrina ManniDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Alessandro CasellatoDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Paolo MacaccaroDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Nicola VituloDepartment of Biology, Interdepartmental Research Center for Biotechnologies (CRIBI) Biotechnology Center, University of Padova, Padova, Italy.
Sara ZumerleDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Odile FilholInstitut National de la Santé Et de la Recherche Médicale (INSERM) U1036, Institute de Recherches en Technologies et Sciences pour le Vivant/Biologie du Cancer et de l'Infection, Grenoble, France.
Brigitte BoldyreffKinase Detect ApS, Krusaa, Denmark.
Christian W SiebelDepartment of Discovery Oncology, Genentech, Inc., South San Francisco, CA, United States.
Antonella ViolaDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Giorgio ValleDepartment of Biology, Interdepartmental Research Center for Biotechnologies (CRIBI) Biotechnology Center, University of Padova, Padova, Italy.
Federica MainoldiIFOM-ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.
Stefano CasolaIFOM-ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.
Valeria CancilaTumor Immunology Unit, University of Palermo, Palermo, Italy.
Alessandro GulinoTumor Immunology Unit, University of Palermo, Palermo, Italy.
Claudio TripodoIFOM-ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.
Marco PizziDepartment of Medicine, Cytopathology and Surgical Pathology Unit, University of Padova, Padova, Italy.
Angelo Paolo Dei TosDepartment of Medicine, Cytopathology and Surgical Pathology Unit, University of Padova, Padova, Italy.
Livio TrentinDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Gianpietro SemenzatoDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
Francesco PiazzaDepartment of Medicine, Division of Hematology, University of Padova, Padova, Italy.
University of Padua · ITVeneto Institute of Molecular Medicine · ITUniversity of Palermo · ITFIRC Institute of Molecular Oncology · ITBoston Children's Hospital · USInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serine-Threonine kinase CK2 supports malignant B-lymphocyte growth but its role in B-cell development and activation is largely unknown. Here, we describe the first B-cell specific knockout (KO) mouse model of the β regulatory subunit of CK2. CK2β

Indexed as

Casein Kinase IILymphocyte ActivationAnimalsCell DifferentiationMiceMice, KnockoutProtein Serine-Threonine KinasesReceptors, Antigen, B-CellSheepSignal TransductionCasein Kinase IIProtein Serine-Threonine KinasesReceptors, Antigen, B-CellB cell developmentB cell receptor signalingB lymphocyteDiffuse large B cell lymphomagerminal centermarginal zoneprotein kinase CK2

Identifiers

PMID36713383
PMCPMC9874936
OpenAlexW4315649529

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.