SynthesisFrontiers in immunology2022
Safety of COVID-19 vaccination in women undergoing IVF/ICSI treatment - Clinical study and systematic review.
Synthesis in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Effect of COVID-19 vaccination on the outcome ofFrontiers in public health · 2023Pooled it
- Prior COVID-19 infection increases degenerated oocytes but does not affect IVF outcomes: a prospective cohort study.Frontiers in endocrinology · 2025Observational
- Associations between inactivated COVID-19 vaccination status and timing and fertility and pregnancy outcomes following frozen-thawed embryo transfer: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Effects of COVID-19 convalescence on pregnancy outcomes in frozen-thawed embryo transfer: A retrospective cohort study.PloS one · 2025Article
- The Effect of COVID-19 and COVID-19 Vaccination on Assisted Human Reproduction Outcomes: A Systematic Review and Meta-Analysis.Diseases (Basel, Switzerland) · 2024Review
- The direct effect of SARS-CoV-2 virus vaccination on human ovarian granulosa cells explains menstrual irregularities.NPJ vaccines · 2024Article
- Fertility outcomes in women undergoing Assisted Reproductive Treatments after COVID-19 vaccination: A prospective cohort study.International journal of fertility & sterility · 2024Article
- The impact of SARS-CoV-2 mRNA vaccine on intracytoplasmic sperm injection outcomes at a fertility center in Iraq: A prospective cohort study.Health science reports · 2024Article
- COVID-19 Vaccination and Reproductive Health: a Comprehensive Review for Healthcare Providers.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Lack of association between COVID-19 vaccines and miscarriage onset using a case-crossover design.Scientific reports · 2024Article
- The type of COVID-19 vaccination does not affect reproductive function and pregnancy outcomes in infertile couples.Frontiers in endocrinology · 2024Article
- COVID-19 Vaccines and Assisted Reproductive Techniques: A Systematic Review.Journal of personalized medicine · 2023Review
- COVID-19 Pharmacotherapy in Pregnancy: A Literature Review of Current Therapeutic Choices.Viruses · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: It was suggested that vaccination in general might affect reproductive health. Safety of COVID-19 vaccination in women undergoing assisted reproductive techniques (ART) treatment is not well established. Methods: We performed a retrospective study including 536 women undergoing fresh embryo transfer after IVF/ICSI treatment in a huge IVF center in southern China to investigate the effect of COVID-19 vaccination on oocyte maturation, fertilization rate, blastulation rate, implantation rate, clinical pregnancy rate and miscarriage rate. In addition, we performed a systematic review of existing studies on the safety of COVID-19 vaccination in women undergoing ART treatment. Results: In our study, 268 women received inactivated or recombinant COVID-19 vaccination and 268 controls were enrolled based on propensity score matching. We observed a decreased fertilization rate and signs for impaired oocyte maturation in vaccinated women. Besides our study, there were 15 studies analyzing the safety of COVID-19 vaccination in women undergoing ART treatment. For the mRNA vaccines, no adverse signals were reported concerning oocyte maturation, fertilization rate, blastulation rate, implantation rate, clinical pregnancy rate and miscarriage rate. In women being vaccinated with an inactivated vaccine, implantation rate, clinical pregnancy rate and miscarriage rate were not affected, whereas oocyte maturation and fertilization rate were impaired. Conclusions: Vaccination against COVID-19 in women undergoing ART treatment seems to be safe especially for women getting mRNA vaccines. The effects on oocyte maturation and fertilization rate of inactivated and recombinant COVID-19 vaccinations might be a safety signal and need further investigation and independent confirmation.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.