ArticleFrontiers in immunology2022
The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 6 of them syntheses that pooled it.
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Who cites it
142 citing papers in PubMed, 6 syntheses or guidelines pooled it, 219 citations in OpenAlex.
- Pooled it
- The effect of physical activity on sleep disorders in pregnant people: a meta-analysis of randomized controlled trials.BMC pregnancy and childbirth · 2025Pooled it
- Impact of exercise type, duration, and intensity on depressive symptoms in older adults: a systematic review and meta-analysis.Frontiers in psychology · 2024Pooled it
- Pooled it
- Unraveling the link between hypertension and depression in older adults: a meta-analysis.Frontiers in public health · 2023Pooled it
- The effects of different types of Tai Chi exercise on anxiety and depression in older adults: a systematic review and network meta-analysis.Frontiers in public health · 2023Pooled it
- Esketamine Optimized the Efficacy of Dexmedetomidine in Treating Sleep Disorders with Comorbid Depression.Neuropsychiatric disease and treatment · 2025Trial
- Association between ln(FPG/HDL-C) × BMI and self-reported obstructive sleep apnea: A cross-sectional study using NHANES data.Medicine · 2026Article
- Causal Associations Between Sedentary Time and Sleep Traits.Brain and behavior · 2026Article
- Altered Progesterone Receptor Isoform Expression in Endometrial Cells: A Preliminary Immunohistochemical Study in Endometriosis.Journal of clinical medicine · 2026Article
- Integrating Sleep, Eating, Bowel Habits, and Physical Activity in Children and Adolescents: A Conceptual Review of the Four Kai Framework.Children (Basel, Switzerland) · 2026Review
- Article
- Association of Domain-Specific Physical Activity with Sleep Disorders in U.S. Adults: A Cross-Sectional Study Based on NHANES.Healthcare (Basel, Switzerland) · 2026Article
- Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study.Journal of advanced research · 2026Article
- 24-hour movement behaviors patterns and their influencing factors in patients with coronary heart disease: a latent profile analysis.BMC cardiovascular disorders · 2026Article
- Predictors of Performing Function Focused Care.International journal of older people nursing · 2026Article
- Inflammaging and Sarcopenia as Interconnected Hallmarks of Aging: Integrative Roles of Bioactive Compounds and Lifestyle Interventions.Nutrients · 2026Review
- The inverse association between skeletal muscle mass to visceral fat ratio (SVR) and sleep disturbance: the mediating role of inflammation and aging acceleration.BMC psychiatry · 2026Article
- Associations of sedentary behavior and physical activity with sleep disorders in patients with osteoarthritis: The mediating role of inflammatory biomarkers.Osteoarthritis and cartilage open · 2026Article
- The inflammation-nutrition axis and survival outcomes: Role of the neutrophil percentage-to-albumin ratio in patients with sleep disorders.The Journal of international medical research · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Two related lifestyle behaviors associated with sleep disturbance are sedentary behavior and physical exercise participation. We aimed to use a population-based study to disentangle the relationships between sedentary behavior, exercise, and sleep disturbance based on blood-cell-based inflammatory biomarkers. Methods: A total of 22,599 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Sleep disturbance was assessed according to the NHANES questionnaire. Exercise participation ansd sedentary behavior were evaluated by the global physical activity questionnaire. The inflammatory biomarkers in the examination were white blood cell (WBC) count, neutrophil count (NEU), neutrophil-to-lymphocyte ratio (NLR), and systemic immune inflammation index (SII). A complex multistage sampling design and weighted multivariable logistic regression were applied for further analysis. Mediation models were constructed to figure out the mediating role of inflammatory biomarkers. Results: The weighted prevalence of sleep disturbance was 24.17%. Sedentary behavior and exercise were associated with sleep disturbance after full adjustment [for sedentary behavior, OR (95% CI): 1.261 (1.154, 1.377); for exercise, OR (95% CI): 0.849 (0.757, 0.953)]. In severe sedentary behavior groups, the mitigation effect of exercise on sleep disturbance was observed [OR (95% CI): 0.687 (0.551, 0.857)]. For the mechanism, strong associations were detected between inflammatory biomarkers and sleep disturbance. Mediation analysis showed that WBC, NEU, NLR, and SII mediated the statistical association between sedentary behavior and sleep disturbance with proportions (%) of 2.09, 2.27, 1.76, and 0.82, respectively. Conclusions: Our data suggested that sedentary behavior was a risk factor for sleep disturbance. Blood-cell-based inflammatory biomarkers were an easily accessible and cost-effective strategy for identifying sleep disturbance and also significantly mediated the association between sedentary behavior and sleep disturbance. Exercise was proved to be effective in severe sedentary behavior groups to improve sleep disturbance symptoms, while the internal mechanism needed further exploration.
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