SynthesisFrontiers in endocrinology2022

Association of metformin use with fracture risk in type 2 diabetes: A systematic review and meta-analysis of observational studies.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation · may be no link

−9%−19% to +2%

Bigger than 3 in 10 for adverse events & safety

As reported

RR 0.91, 95% CI 0.81–1.02

the abstract, start to end

… with a decreased risk of fracture (RR, 0.91; 95% CI, 0.81-1.02; I …

← favours treatmentfavours comparator →

could be chance

Adverse events & safety

RR 0.910.81–1.02

MetforminAdverse events & safety

1 / 3

2022

2023

2024

2025

2026

this papercites it