Evidence map›Paper›PMID 36714811›Full record

ArticleJID innovations : skin science from molecules to population health2023

Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk.

Luke H Johnson, Heehwa G Son, Dat Thinh Ha, John D Strickley, Joongho Joh, Shadmehr Demehri

Open access · goldAbstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Luke H JohnsonUniversity of Louisville School of Medicine, Louisville, Kentucky, USA.
Heehwa G SonCenter for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Dat Thinh HaCenter for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
John D StrickleyUniversity of Louisville School of Medicine, Louisville, Kentucky, USA.
Joongho JohDepartment of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Shadmehr DemehriCenter for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USUniversity of Louisville · US

Funding

Immunity to commensal papillomaviruses for cancer therapyR01CA251755 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DEMEHRI, SHADMEHR, JOH, JOONGHO JOHN · 2021 to 2025
$2.6M
NCI NIH HHS R01 CA251755
6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human papillomavirus viral load and seropositivity observed among patients with cSCC. Experimental data in mice colonized with mouse papillomavirus type 1 suggest that T cell immunity against β-human papillomavirus suppresses skin cancer in immunocompetent hosts, and the loss of this immunity leads to the increased risk of cSCC. In this study, we show that CD8

Indexed as

ab, antibodycSSC, cutaneous squamous cell carcinomaDMBA, 7,12-dimethylbenz[a]anthraceneHPV, human papillomavirusMmuPV1, mouse papillomavirus type 1UVB, ultraviolet B

Identifiers

PMID36714811
PMCPMC9879970
OpenAlexW4298004420

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.