Evidence map›Paper›PMID 36715756›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2023

Efficacy and safety of erythropoietin in isolated spinal metastasis patients with total en bloc spondylectomy surgery: a case-control study.

Shuang Cao, Kai Lv, Cheng Peng, Guangjian Bai, Xin Gao, Jing Wang, Jiashi Cao, Rende Ning, Jianjun Chu, Tielong Liu

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuang Cao *Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Kai Lv *Department of Orthopedics, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Cheng Peng *Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Guangjian Bai *Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xin GaoDepartment of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jing WangDepartment of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jiashi CaoDepartment of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Rende NingDepartment of Orthopedics, Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China. nrd192@qq.com.
Jianjun ChuDepartment of Orthopedics, The Second People's Hospital of Hefei, Hefei, Anhui Province, China. chujianjun@163.com.
Tielong LiuDepartment of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. liutielongvip@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of our study is to identify the effect of short-term and high-dose use of erythropoietin (EPO) in spinal isolated metastatic patients with Total en bloc spondylectomy (TES) surgery by assessing hematological parameters, transfusion volume, postoperative complications, recurrence-free survival (RFS), and overall survival (OS).

methodsFrom January 2015 and January 2022, 93 isolated spinal metastasis patients were selected and separated into 2 groups based on the treatment method used (EPO + TXA (Tranexamic acid) group, n = 47; and TXA group, n = 46). Indexes for evaluation included hemoglobin (Hb), hematocrit (Hct), red blood cells (RBC), RFS, OS, postoperative complications, postoperative Frankel Grade, drainage volume, transfusion rate, and mean units transfused.

resultsThe average follow-up duration was 38.13 months. There was no significant difference (P > 0.05) in RFS, OS, postoperative complications, postoperative Frankel Grade, drainage volume, and transfusion rate between the two groups. However, patients in EPO + TXA group have significantly higher Hb, Hct, and RBC values than those in the TXA group on postoperative days 1, 2, 3, and 5. Moreover, the mean transfusion volume in EPO + TXA group was significantly lower than those in the TXA group (P = 0.011).

conclusionsPerioperative short-term and high-dose administration of EPO could improve the anemia-related hematological parameters and reduce the requirement for blood transfusion without increasing the risk of deep vein thrombosis and tumor progression in solitary spinal metastatic patients with TES surgery.

Indexed as

Antifibrinolytic AgentsErythropoietinSpinal NeoplasmsBlood Loss, SurgicalCase-Control StudiesHumansPostoperative ComplicationsAntifibrinolytic AgentsErythropoietinErythropoietinIsolated spinal metastasisRecurrence-free survivalTotal en bloc spondylectomyTransfusion

Identifiers

PMID36715756

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.