Evidence map›Paper›PMID 36717228›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Postsynaptic NMDA Receptor Expression Is Required for Visual Corticocollicular Projection Refinement in the Mouse Superior Colliculus.

Kristy O Johnson, Leeor Harel, Jason W Triplett

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  3. Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kristy O JohnsonCenter for Neuroscience Research, Children's National Research Institute, Washington, DC 20010.
Leeor HarelCenter for Neuroscience Research, Children's National Research Institute, Washington, DC 20010.
Jason W TriplettCenter for Neuroscience Research, Children's National Research Institute, Washington, DC 20010 jtriplett@childrensnational.org.ORCID 0000-0002-8064-3617
Children's National · US

Funding

Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
Mechanisms of Synaptic Specificity in Visual CircuitsR01EY025627 · NEI · CHILDREN'S RESEARCH INSTITUTE · PI TRIPLETT, JASON · 2015 to 2025
$4.5M
NEI NIH HHS R01 EY025627NICHD NIH HHS P50 HD105328
6 · The paper itself

Abstract

Efficient sensory processing of spatial information is facilitated through the organization of neuronal connections into topographic maps of space. In integrative sensory centers, converging topographic maps must be aligned to merge spatially congruent information. The superior colliculus (SC) receives topographically ordered visual inputs from retinal ganglion cells (RGCs) in the eye and layer 5 neurons in the primary visual cortex (L5-V1). Previous studies suggest that RGCs instruct the alignment of later-arriving L5-V1 inputs in an activity-dependent manner. However, the molecular mechanisms underlying this remain unclear. Here, we explored the role of NMDA receptors in visual map alignment in the SC using a conditional genetic knockout approach. We leveraged a novel knock-in mouse line that expresses tamoxifen-inducible Cre recombinase under the control of the

Indexed as

Receptors, N-Methyl-D-AspartateSuperior ColliculiAnimalsMiceRetinal Ganglion CellsSensationVisual PathwaysReceptors, N-Methyl-D-Aspartatealignmentmap alignmentTal1topographic maptopographyvisual

Identifiers

PMID36717228
PMCPMC9987568
OpenAlexW4318499223

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.