Evidence map›Paper›PMID 36717541›Full record

ReviewThe Journal of international medical research2023

Highlights on molecular targets in the management of COVID-19: Possible role of pharmacogenomics.

Romany H Thabet, Noor A Massadeh, Omar B Badarna, Omar M Al-Momani

Open access · goldAbstract readReview
In one paragraph

Review in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Romany H ThabetDepartment of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0000-0001-9566-4034
Noor A MassadehInternship, Princess Basma Hospital, Ministry of Health, Irbid, Jordan.ORCID 0000-0002-6198-0183
Omar B BadarnaInternship, Princess Basma Hospital, Ministry of Health, Irbid, Jordan.
Omar M Al-MomaniInternship, Princess Basma Hospital, Ministry of Health, Irbid, Jordan.
Ministry of Health · JOYarmouk University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By the end of 2022, there had been a reduction in new cases and deaths caused by coronavirus disease 2019 (COVID-19). At the same time, new variants of the severe acute respiratory syndrome coronavirus 2 virus were being discovered. Critically ill patients with COVID-19 have been found to have high serum levels of proinflammatory cytokines, especially interleukin (IL)-6. COVID-19-related mortality has been attributed in most cases to the cytokine storm caused by increased levels of inflammatory cytokines. Dexamethasone in low doses and immunomodulators such as IL-6 inhibitors are recommended to overcome the cytokine storm. This current narrative review highlights the place of other therapeutic choices such as proteasome inhibitors, protease inhibitors and nuclear factor kappa B inhibitors in the treatment of patients with COVID-19.

Indexed as

COVID-19Cytokine Release SyndromeCytokinesHumansInterleukin-6PharmacogeneticsSARS-CoV-2CytokinesInterleukin-6COVID-19cytokine storminerleukin-6pharmacogenomicsproteasome inhibitors

Identifiers

PMID36717541
PMCPMC9893104
OpenAlexW4318570243

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.