ArticleTherapeutic advances in respiratory disease
Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality.
Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01245933 (Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis and Utilisation of Health Care Resources in Patients With COPD), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis and Utilisation of Health Care Resources in Patients With COPD
Who cites it
28 citing papers in PubMed, 30 citations in OpenAlex.
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Borderline Forced Expiratory Volume in 1 Second to Forced Vital Capacity and Low Forced Expiratory Volume in 1 Second Predict Disease Progression in High-Risk Populations With COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Precision treatment of COPD based on novel imaging phenotypes: a treatable traits approach.Respiratory research · 2026Review
- The impact of neighbourhood material and social disadvantage on respiratory health across Canada.The European respiratory journal · 2026Article
- Clinically relevant change in airway wall thickness to identify disease activity in COPD and smokers at risk.The European respiratory journal · 2026Article
- Relationship between quantitative CT and cardiac function in patients with severe COPD exacerbations (ECOPD).BMJ open respiratory research · 2026Article
- Small Airway Dysfunction in Chronic Obstructive Pulmonary Disease Pathology: Assessment and Clinical Implications.Tuberculosis and respiratory diseases · 2026Article
- CT image-based machine learning models for predicting blood eosinophil levels in acute exacerbation of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
- Beyond spirometry: understanding COPD origins to support a new diagnostic approach.ERJ open research · 2026Review
- Mapping the trajectory from pre-COPD to COPD: predictive value of symptoms, imaging, and physiologic abnormalities.Annals of the American Thoracic Society · 2026Article
- Correlation analysis of chest HRCT quantitative parameters, exhaled nitric oxide, and pulmonary function in patients with chronic obstructive pulmonary disease.Scientific reports · 2026Article
- Airway Quantification Using Ultra-Low-Dose Computed Tomography Correlates With Pulmonary Function Indices in Patients With Asthma.Journal of Korean medical science · 2026Article
- Cardiopulmonary Exercise Testing and Quantitative Chest CT in COPD: The Stronger Association of Emphysema Over Airway Thickness with Functional Impairment.International journal of chronic obstructive pulmonary disease · 2026Article
- Quantitative Analysis of Bronchiectasis in Alpha-1 Antitrypsin Deficiency.Canadian respiratory journal · 2026Article
- Association of AI-Derived Quantitative CT Parameters of Airway, Emphysema, and Pulmonary Vasculature with Lung Cancer: A Cross-Sectional AnalysisCurrent medical imaging · 2026Article
- Detection of Airway Remodeling in Asthma Using Bronchoscopic Optical Coherence Tomography.CHEST pulmonary · 2025Article
- Airway wall thickness in asthma remission.ERJ open research · 2025Article
- Characteristics Associated with Lung Function Trajectories: An Analysis of the SPIROMICS Cohort.Annals of the American Thoracic Society · 2025Article
- The Association of Interstitial Lung Abnormalities and Preserved Ratio Impaired Spirometry With Mortality.Chest · 2025Observational
- The Emerging Biomarkers in Chronic Obstructive Pulmonary Disease: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChest computed tomography (CT) is increasingly used for phenotyping and monitoring of patients with COPD. The aim of this work was to evaluate the association of Pi10 as a measure of standardized airway wall thickness on CT with exacerbations, mortality, and response to triple therapy.
methodsPatients of GOLD grades 1-4 of the COSYCONET cohort with prospective CT scans were included. Pi10 was automatically computed and analyzed for its relationship to COPD severity, comorbidities, lung function, respiratory therapy, and mortality over a 6-year period, using univariate and multivariate comparisons.
resultsWe included
conclusionIn summary, Pi10 was found to be predictive for the course of the disease in COPD, in particular mortality. The fact that Pi10 was lower in patients with severe COPD receiving triple therapy might hint toward additional effects of this functional therapy on airway remodeling. REGISTRATION: ClinicalTrials.gov, Identifier: NCT01245933.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.