ArticleApplied biochemistry and biotechnology2023
Deletion of ORM2 Causes Oleic Acid-Induced Growth Defects in Saccharomyces cerevisiae.
Article in Applied biochemistry and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast.Cells · 2026Article
- Orm2 promotes nitrogen-induced sphingolipid production and endocytosis via Orm1 phosphorylation.Journal of lipid research · 2025Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The endoplasmic reticulum (ER) resident proteins of the Orm family (Orm1p and Orm2p) play an essential regulatory role in sphingolipid metabolism and proteostasis of Saccharomyces cerevisiae. Sphingolipid metabolism and its relationship with yeast ORM1 and ORM2 have been studied widely, but its position in phospholipids and neutral lipids requires further studies. We found that the deletion of ORM2 reduced phospholipid levels, but orm1Δ had shown no significant alteration of phospholipids. On the contrary, neutral lipid levels and lipid droplet (LD) numbers were increased in both orm1∆ and orm2∆ cells. Unlike orm1Δ, free fatty acid (FFA) levels were steeply accumulated in orm2∆ cells, and deletion of ORM2 made the cells more sensitive towards oleic acid toxicity. Misregulation of fatty acids has been implicated in the causation of several lipid metabolic disorders. It is imminent to comprehend the control mechanisms of free fatty acid homeostasis and its pathophysiology. Our study has provided experimental evidence of ORM2 role in the lipid and fatty acid metabolism of yeast.
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