ArticleAging clinical and experimental research2023
Association between B-vitamins intake and frailty among patients with chronic obstructive pulmonary disease.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The association of ultra-processed food intake on age-related muscle conditions: a systematic review and dose-response meta-analysis with meta-regression.Journal of health, population, and nutrition · 2025Pooled it
- Associations between vitamin B6 and vitamin B12 intake and lung function: A cross-sectional study based on NHANES 2007 to 2012.Medicine · 2026Article
- Association between dietary B vitamin intakes and advanced cardiovascular-kidney-metabolic syndrome: insights from the National Health and Nutrition Examination Survey and an external hospital-based dataset.Frontiers in nutrition · 2026Article
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- Phthalate exposure is associated with increased CVD risk in CKD: evidence from NHANES and network toxicology analysis.Renal failure · 2025Article
- Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.npj aging · 2025Article
- Nutritional Support of Chronic Obstructive Pulmonary Disease.Nutrients · 2025Review
- Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study.Frontiers in nutrition · 2025Article
- Development and validation of a nomogram for predicting pulmonary complications in elderly patients undergoing thoracic surgery.Aging clinical and experimental research · 2024Article
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- Decreased cobalamin sensitivity and biological aging acceleration in the general population.The journal of nutrition, health & aging · 2024Article
- The Role of Nutrition in the Development and Management of Chronic Obstructive Pulmonary Disease.Nutrients · 2024Review
- Association between oxidative balance score and frailty in chronic obstructive pulmonary disease.Heliyon · 2024Article
- Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review.Nutrients · 2024Review
- Article
- A Mendelian randomization study to examine the causal associations of circulating micronutrient levels with frailty risk.Frontiers in nutrition · 2024Article
- Genetic information supports a causal relationship between trace elements, inflammatory proteins, and COPD: evidence from a Mendelian randomization analysis.Frontiers in nutrition · 2024Article
- Association between serum pyridoxal 5'-phosphate levels and chronic obstructive pulmonary disease: findings based on NHANES 2005-2010.Frontiers in nutrition · 2024Article
- The Association Between Dietary Magnesium Intake and Frailty in Patients with Chronic Obstructive Pulmonary Disease: National Health and Nutrition Examination Survey.International journal of chronic obstructive pulmonary disease · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeGain insight into the impact of B vitamins, including vitamin B1, vitamin B2, niacin, vitamin B6, total folate, and vitamin B12 on the risk of frailty in patients with chronic obstructive pulmonary disease (COPD).
methodsThis study was an American population-based cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES). A total of 1201 COPD patients were included in the analysis. Of these, the intake of B vitamins was determined by the two 24-h recall interviews. We followed the method constructed by Hakeem et al. to calculate the frailty index (FI), which is used as a reliable tool to assess the debilitating status of patients with COPD. Missing data were imputed by the MissForest method based on random forests. Multivariate logistic regression model and inverse probability weighted based on propensity scores were used to correct for confoundings.
resultsLogistic regression models showed that vitamin B6 intake was negatively correlated with frailty risk in COPD patients, while other B vitamins including B1, B2, niacin (vitamin B3), total folic acid and vitamin B12 were not. After adjusting for covariates, the association between vitamin B6 and frailty risk (adjusted OR = 0.80, 95%CI = 0.66-0.95, P = 0.013) remained significant. At the same time, sensitivity analysis proves the robustness of the results.
conclusionCOPD patients with lower vitamin B6 intake have a higher risk of frailty. However, intake of vitamin B1, B2, niacin, total folic acid, and vitamin B12 was not associated with frailty risk in COPD patients.
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Registered trials
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