Evidence map›Paper›PMID 36719780›Full record

ArticleTissue engineering. Part C, Methods2023

Implanted Tissue-Engineered Vascular Graft Cell Isolation with Single-Cell RNA Sequencing Analysis.

Gabriel J M Mirhaidari, Jenny C Barker, Christopher K Breuer, James W Reinhardt

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part C, Methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. 3D bioprinting for bile duct tissue engineering: current status and prospects.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

  • Erratum issued
    2023
5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gabriel J M MirhaidariCenter for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0003-0665-7268
Jenny C BarkerCenter for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Christopher K BreuerCenter for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
James W ReinhardtCenter for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Nationwide Children's Hospital · US

Funding

Advanced Research Training in Immunology for Surgery Trainees (ARTIST)T32AI106704 · NIAID · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER, Jon R Wisler · 2014 to 2026
$3.5M
Elucidating the Molecular Mechanisms Underlying LYST-mediated Tissue Engineered Vascular Graft StenosisR01HL157491 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE · 2021 to 2024
$2.9M
Modulating the Host Response to Tissue Engineered Vascular GraftsF32HL144120 · NHLBI · OHIO STATE UNIVERSITY · PI BARKER, JENNY CATHRYN · 2019 to 2021
$103k
NHLBI NIH HHS F32 HL144120NHLBI NIH HHS R01 HL157491NIAID NIH HHS T32 AI106704
6 · The paper itself

Abstract

The advent of single-cell RNA sequencing (scRNA-Seq) has brought with it the ability to gain greater insights into the cellular composition of tissues and heterogeneity in gene expression within specific cell types. For tissue-engineered blood vessels, this is particularly impactful to better understand how neotissue forms and remodels into tissue resembling a native vessel. A notable challenge, however, is the ability to separate cells from synthetic biomaterials to generate high-quality single-cell suspensions to interrogate the cellular composition of our tissue-engineered vascular grafts (TEVGs) during active remodeling

Indexed as

Blood Vessel ProsthesisTissue EngineeringAnimalsBiocompatible MaterialsMiceSequence Analysis, RNASuspensionsTissue ScaffoldsBiocompatible MaterialsSuspensionsbiomaterialsremodelingscaffoldsingle-cell RNA sequencingtissue-engineered vascular grafts

Identifiers

PMID36719780
PMCPMC9968626
OpenAlexW4318667756

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.