SynthesisEuropean heart journal2023
Endovascular revascularization strategies for aortoiliac and femoropopliteal artery disease: a meta-analysis.
Synthesis in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Comparison of clinical outcomes of drug-coated balloons angioplasty vs. plain old balloons angioplasty for peripheral arterial disease: an umbrella meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Proximal plaque cap morphology in femoropopliteal occlusion affects the primary patency of endovascular therapy: a CT angiography cohort study.La Radiologia medica · 2026Article
- Intravascular imaging in peripheral arterial disease: a contemporary literature review.European heart journal open · 2026Review
- Major Adverse Limb Events and Death After Successful Endovascular Revascularization: BEST-CLI Trial.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Giant Pseudoaneurysm as an Uncommon Late Complication Following a Fourteen-Year Femoropopliteal Bypass in a Visually Impaired Patient.Diagnostics (Basel, Switzerland) · 2026Article
- Optimal endovascular strategy for femoropopliteal claudication and infrapopliteal CLTI: a network meta-analysis stratified by lesion length.Cardiovascular intervention and therapeutics · 2026Article
- Systematic Review, Meta-analysis, and Trial Sequential Analysis of Randomised Controlled Trials Comparing Balloon Expandable with Self Expanding Stents for the Treatment of Iliac Artery Occlusive Disease.EJVES vascular forum · 2026Review
- Ultrasound-guided adjunct to endovascular treatment of long-segment femoropopliteal chronic total occlusion.European journal of medical research · 2025Article
- Comparable clinical characteristics and outcomes of patients undergoing endovascular treatment for aorto-iliac or femoropopliteal lesions.Cardiovascular intervention and therapeutics · 2025Article
- Drug-coated balloon with bailout stenting versus drug-eluting stent plus drug-coated balloon in TransAtlantic Inter-Society Consensus C and D femoropopliteal lesions: a propensity score-matched analysis.Quantitative imaging in medicine and surgery · 2025Article
- Drug-coated balloon treatment for tasc c/d infrapopliteal disease: Two-year matched cohort outcomes.Biomolecules & biomedicine · 2025Article
- Efficacy of drug-coated balloon for repeated short-term restenosis of dialysis arteriovenous fistulas.Acta radiologica open · 2025Article
- Femoropopliteal Interventions for Peripheral Artery Disease: A Review of Current Evidence and Future Directions.Interventional cardiology clinics · 2025Review
- Algorithm for the Revascularization of Infrainguinal Arterial Disease.Vascular specialist international · 2025Review
- Early outcomes of drug-coated balloon angioplasty and stent placement for the treatment of iliac artery lesions.Frontiers in surgery · 2025Article
- In-House Fabrication and Validation of 3D-Printed Custom-Made Medical Devices for Planning and Simulation of Peripheral Endovascular Therapies.Diagnostics (Basel, Switzerland) · 2024Article
- Appropriateness of Care Measures: A Novel Approach to Quality.Annals of vascular surgery · 2024Article
- Effectiveness of Atherectomy and Drug-Coated Balloon Angioplasty in Femoropopliteal Disease: A Comprehensive Outcome Study.Vascular specialist international · 2024Article
- Drug-eluting devices for lower limb peripheral arterial disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Review
- Article
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Authors and funding
15 authors at 7 institutions in 8 countries.
Funding
Abstract
aimsOptimal endovascular management of intermittent claudication (IC) remains disputed. This systematic review and meta-analysis compares efficacy and safety outcomes for balloon angioplasty (BA), bare-metal stents (BMS), drug-coated balloons (DCB), drug-eluting stents (DES), covered stents, and atherectomy. METHODS AND
resultsElectronic databases were searched for randomized, controlled trials (RCT) from inception through November 2021. Efficacy outcomes were primary patency, target-lesion revascularization (TLR), and quality-of-life (QoL). Safety endpoints were all-cause mortality and major amputation. Outcomes were evaluated at short-term (<1 year), mid-term (1-2 years), and long-term (≥2 years) follow-up. The study was registered on PROSPERO (CRD42021292639). Fifty-one RCTs enrolling 8430 patients/lesions were included. In femoropopliteal disease of low-to-intermediate complexity, DCBs were associated with higher likelihood of primary patency [short-term: odds ratio (OR) 3.21, 95% confidence interval (CI) 2.44-4.24; long-term: OR 2.47, 95% CI 1.93-3.16], lower TLR (short-term: OR 0.33, 95% CI 0.22-0.49; long-term: OR 0.42, 95% CI 0.29-0.60) and similar all-cause mortality risk, compared with BA. Primary stenting using BMS was associated with improved short-to-mid-term patency and TLR, but similar long-term efficacy compared with provisional stenting. Mid-term patency (OR 1.64, 95% CI 0.89-3.03) and TLR (OR 0.50, 95% CI 0.22-1.11) estimates were comparable for DES vs. BMS. Atherectomy, used independently or adjunctively, was not associated with efficacy benefits compared with drug-coated and uncoated angioplasty, or stenting approaches. Paucity and heterogeneity of data precluded pooled analysis for aortoiliac disease and QoL endpoints.
conclusionCertain devices may provide benefits in femoropopliteal disease, but comparative data in aortoiliac arteries is lacking. Gaps in evidence quantity and quality impede identification of the optimal endovascular approach to IC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.