Evidence map›Paper›PMID 36724801›Full record

ArticleHypertension (Dallas, Tex. : 1979)2023

Combined Statin and Glucocorticoid Therapy for the Safer Treatment of Preterm Birth.

Andrew D Kane, Emilio A Herrera, Youguo Niu, Emily J Camm, Beth J Allison, Deodata Tijsseling, Ciara Lusby, Jan B Derks, Kirsty L Brain, Inge M Bronckers and 3 more

Open access · hybridFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Andrew D Kane *Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).ORCID 0000-0001-9488-4086
Emilio A Herrera *Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).ORCID 0000-0002-6342-085X
Youguo NiuDepartment of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).
Emily J CammDepartment of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).
Beth J AllisonDepartment of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).ORCID 0000-0002-1060-513X
Deodata TijsselingPerinatal Center, University Medical Center, Utrecht, the Netherlands (D.T., J.B.D.).
Ciara LusbyDepartment of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).
Jan B DerksPerinatal Center, University Medical Center, Utrecht, the Netherlands (D.T., J.B.D.).
Kirsty L BrainDepartment of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).ORCID 0000-0002-5566-7748
Inge M BronckersDepartment of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, the Netherlands (I.M.B.).
Christine M CrossDepartment of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).
Lindsey BerendsInstitute of Metabolic Science, University of Cambridge Metabolic Research Laboratories, Addenbrooke's Hospital, Cambridge, United Kingdom (L.B.).
Dino A GiussaniDepartment of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (A.D.K., E.A.H., Y.N., E.J.C., B.J.A., C.L., K.L.B., C.M.C., D.A.G.).ORCID 0000-0002-1308-1204
Anna Needs Neuroblastoma Answers · USHudson Institute of Medical Research · AUUniversity Medical Center Utrecht · NLUniversity of Cambridge · GBRadboud University Nijmegen · NLWellcome/MRC Institute of Metabolic Science · GB

Funding

Biotechnology and Biological Sciences Research CouncilBritish Heart Foundation RG/17/8/32924
6 · The paper itself

Abstract

backgroundPrematurity is strongly associated with poor respiratory function in the neonate. Rescue therapies include treatment with glucocorticoids due to their anti-inflammatory and maturational effects on the developing lung. However, glucocorticoid treatment in the infant can increase the risk of long-term cardiovascular complications including hypertension, cardiac, and endothelial dysfunction. Accumulating evidence implicates a molecular link between glucocorticoid excess and depletion of nitric oxide (NO) bioavailability as a mechanism underlying the detrimental effects of postnatal steroids on the heart and circulation. Therefore, combined glucocorticoid and statin therapy, by increasing NO bioavailability, may protect the developing cardiovascular system while maintaining beneficial effects on the lung.

methodsWe investigated combined glucocorticoid and statin therapy using an established rodent model of prematurity and combined experiments of cardiovascular function in vivo, with those in isolated organs as well as measurements at the cellular and molecular levels.

resultsWe show that neonatal glucocorticoid treatment increases the risk of later cardiovascular dysfunction in the offspring. Underlying mechanisms include decreased circulating NO bioavailability, sympathetic hyper-reactivity, and NO-dependent endothelial dysfunction. Combined neonatal glucocorticoid and statin therapy protects the developing cardiovascular system by normalizing NO and sympathetic signaling, without affecting pulmonary maturational or anti-inflammatory effects of glucocorticoids.

conclusionsTherefore, combined glucocorticoid and statin therapy may be safer than glucocorticoids alone for the treatment of preterm birth.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsPremature BirthAnti-Inflammatory AgentsDexamethasoneFemaleGlucocorticoidsHumansInfant, NewbornInfant, PrematureAnti-Inflammatory AgentsDexamethasoneGlucocorticoidsHydroxymethylglutaryl-CoA Reductase Inhibitorscardiovascular diseasesglucocorticoidshypertensioninfantnewbornpremature birth

Identifiers

PMID36724801
PMCPMC10017302
OpenAlexW4318829094

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read52
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.