ArticleNature2023
Structural basis for substrate selection by the SARS-CoV-2 replicase.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Virologic insights from the phase 3 REDPINE trial: remdesivir in renally impaired and immunocompromised patients with COVID-19.Antimicrobial agents and chemotherapy · 2026Trial
- SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants.Antimicrobial agents and chemotherapy · 2025Trial
- No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials.Viruses · 2024Trial
- Structural and Mechanistic Perspectives on SARS-CoV-2 Nonstructural Protein 14-Mediated Cap Formation and Drug Discovery.Microorganisms · 2026Review
- Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.The Journal of biological chemistry · 2026Article
- Positive-Strand RNA Viral RdRps: From Structure Conservation and Activity Assay to Drug Development.Molecules (Basel, Switzerland) · 2026Review
- Article
- Discovering novel multi-target compounds against aspartyl viral polymerases via ligand-based pharmacophore and structure-based screening.Scientific reports · 2026Article
- Article
- Preferential remdesivir triphosphate incorporation by SARS-CoV-2 polymerase is altered to ATP by the S759A mutation.Communications biology · 2026Article
- Article
- Inhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase.NAR molecular medicine · 2026Article
- Dynamical Fragment Molecular Orbital Interaction Analysis of SARS-CoV‑2 RNA-Dependent RNA Polymerase and Remdesivir.ACS omega · 2025Article
- SARS-CoV-2 polyprotein expression and the induction of double-membrane vesicles.Journal of virology · 2025Article
- Structural basis for selective remdesivir incorporation by SARS-CoV-2 polymerase, and S759A resistance.Research square · 2025Article
- Development of GFP-expressing infectious clones for PRRSV using TAR cloning for antiviral drug screening.Npj viruses · 2025Article
- Multi-Component Synthesis of New Fluorinated-Pyrrolo[3,4-International journal of molecular sciences · 2025Article
- The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved.Cell · 2025Article
- SARS-CoV-2 Remdesivir Exposure Leads to Different Evolutionary Pathways That Converge in Moderate Levels of Drug Resistance.Viruses · 2025Article
- Mechanism and spectrum of inhibition of viral polymerases by 2'-deoxy-2'-β-fluoro-4'-azidocytidine or azvudine.NAR molecular medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 2 countries.
Brandon F MaloneLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-7752-9824
Jason K PerryGilead Sciences, Inc., Foster City, CA, USA.ORCID http://orcid.org/0000-0001-5492-0652
Paul Dominic B OlinaresLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3429-6618
Hery W LeeDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-3981-0284
James ChenLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA.
Todd C ApplebyGilead Sciences, Inc., Foster City, CA, USA.
Joy Y FengGilead Sciences, Inc., Foster City, CA, USA.ORCID http://orcid.org/0000-0003-4837-1911
John P BilelloGilead Sciences, Inc., Foster City, CA, USA.ORCID http://orcid.org/0000-0003-4327-1727
Honkit NgThe Evelyn Gruss Lipper Cryo-Electron Microscopy Resource Center, The Rockefeller University, New York, NY, USA.
Johanna SotirisThe Evelyn Gruss Lipper Cryo-Electron Microscopy Resource Center, The Rockefeller University, New York, NY, USA.
Mark EbrahimThe Evelyn Gruss Lipper Cryo-Electron Microscopy Resource Center, The Rockefeller University, New York, NY, USA.
Eugene Y D ChuaNational Center for Cryo-EM Access and Training, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1224-2157
Joshua H MendezNational Center for Cryo-EM Access and Training, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-3317-5654
Ed T EngNational Center for Cryo-EM Access and Training, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8014-7269
Robert LandickDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-5042-0383
Matthias GötteDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Brian T ChaitLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-3524-557X
Elizabeth A CampbellLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA. campbee@rockefeller.edu.ORCID http://orcid.org/0000-0002-1332-128X
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA. darst@rockefeller.edu.ORCID http://orcid.org/0000-0002-8241-3153
Rockefeller University · USGilead Sciences (United States) · USNew York Structural Biology Center · USUniversity of Alberta · CANew York University · USUniversity of Wisconsin–Madison · US
Funding
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MTR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MNational Resource for Mass Spectrom of Biological MacromoleculesP41GM103314 · NIGMS · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T · 2012 to 2017
$9.9MStructure, function, and inhibition of the SARS-CoV-2 replication-transcription complexR01AI161278 · NIAID · ROCKEFELLER UNIVERSITY · PI Seth A. Darst · 2021 to 2026
$3.9MNIAID NIH HHS R01 AI161278NIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM103314NIGMS NIH HHS P41 GM109824NIGMS NIH HHS U24 GM129539
Abstract
The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA synthesis as part of an assembly known as the replication-transcription complex (RTC)
Indexed as
Coronavirus RNA-Dependent RNA PolymeraseCryoelectron MicroscopySARS-CoV-2Adenosine MonophosphateAdenosine TriphosphateAlanineAntiviral AgentsCOVID-19Guanosine TriphosphateHumansNucleosidesRNA CapsRNA, ViralSubstrate SpecificityAdenosine MonophosphateAdenosine TriphosphateAlanineAntiviral AgentsCoronavirus RNA-Dependent RNA PolymeraseGS-441524 triphosphateGuanosine TriphosphateNSP12 protein, SARS-CoV-2NucleosidesremdesivirRNA CapsRNA, Viral
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.