Evidence map›Paper›PMID 36732094›Full record

ReviewTrends in endocrinology and metabolism: TEM2023

Regulation of mTOR by phosphatidic acid.

Maria A Frias, Ahmet Hatipoglu, David A Foster

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Altered Lipid Metabolism in the Vaginal Wall of Women With Pelvic Organ Prolapse: A Targeted Lipidomics Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Multi-omics profile of exceptional long-term survivors of AJCC stage III triple-negative breast cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  14. Review
  15. Review
  16. Review
  17. PI3K Signaling at the Crossroads of Lipid Metabolism and Cancer.Advances in experimental medicine and biology · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Maria A FriasDepartment of Biology and Health Promotion, St. Francis College, Brooklyn, NY 11201, USA; Department of Biological Sciences, Hunter College of the City University of New York, New York, NY 10065, USA. Electronic address: mfrias@sfc.edu.
Ahmet HatipogluDepartment of Biological Sciences, Hunter College of the City University of New York, New York, NY 10065, USA; Biochemistry Program, Graduate Center of the City University of New York, New York, NY 10016, USA.
David A FosterDepartment of Biological Sciences, Hunter College of the City University of New York, New York, NY 10065, USA; Biochemistry Program, Graduate Center of the City University of New York, New York, NY 10016, USA; Biology Program, Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: foster@genectr.hunter.cuny.edu.
The Graduate Center, CUNY · USSt. Francis College · US

Funding

Role of phospholipase D in tumorigenesisR01CA046677 · NCI · HUNTER COLLEGE · PI FOSTER, DAVID A · 1997 to 2014
$3.6M
Dysregulated Metabolic Cell Cycle Checkpoints in Human CancerR01CA179542 · NCI · HUNTER COLLEGE · PI FOSTER, DAVID A · 2014 to 2018
$1.3M
NCI NIH HHS R01 CA046677NCI NIH HHS R01 CA179542
6 · The paper itself

Abstract

mTORC1, the mammalian target of rapamycin complex 1, is a key regulator of cellular physiology. The lipid metabolite phosphatidic acid (PA) binds to and activates mTORC1 in response to nutrients and growth factors. We review structural findings and propose a model for PA activation of mTORC1. PA binds to a highly conserved sequence in the α4 helix of the FK506 binding protein 12 (FKBP12)/rapamycin-binding (FRB) domain of mTOR. It is proposed that PA binding to two adjacent positively charged amino acids breaks and shortens the C-terminal region of helix α4. This has profound consequences for both substrate binding and the catalytic activity of mTORC1.

Indexed as

Phosphatidic AcidsTOR Serine-Threonine KinasesAmino AcidsHumansMechanistic Target of Rapamycin Complex 1Amino AcidsMechanistic Target of Rapamycin Complex 1MTOR protein, humanPhosphatidic AcidsTOR Serine-Threonine KinasesFRBmTORphosphatidic acidphospholipase DRhebstructure

Identifiers

PMID36732094
PMCPMC9957947
OpenAlexW4318620231

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.