Evidence map›Paper›PMID 36732647›Full record

ArticlePediatric research2023

Association of BMAL1 clock gene polymorphisms with fasting glucose in children.

Yi-De Yang, Yuan Zeng, Jian Li, Jun-Hua Zhou, Quan-Yuan He, Chan-Juan Zheng, Christoph Reichetzeder, Bernhard K Krämer, Berthold Hocher

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi-De Yang *Department of Child and Adolescent Health, School of Medicine, Hunan Normal University, 410006, Changsha, China.
Yuan Zeng *Department of Child and Adolescent Health, School of Medicine, Hunan Normal University, 410006, Changsha, China.
Jian LiKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, 410013, Changsha, China.
Jun-Hua ZhouKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China.
Quan-Yuan HeKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China.
Chan-Juan ZhengDepartment of Child and Adolescent Health, School of Medicine, Hunan Normal University, 410006, Changsha, China.
Christoph ReichetzederInstitute of Nutritional Science, University of Potsdam, Potsdam, Germany.
Bernhard K KrämerFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.
Berthold HocherKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, 410013, Changsha, China. berthold.hocher@medma.uni-heidelberg.de.ORCID 0000-0001-8143-0579
Hunan Normal University · CNHeidelberg University · DEUniversity of Potsdam · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe brain and muscle Arnt-like protein-1 (BMAL1) gene is an important circadian clock gene and previous studies have found that certain polymorphisms are associated with type 2 diabetes in adults. However, it remains unknown if such polymorphisms can affect fasting glucose in children and if other factors modify the associations.

methodsA school-based cross-sectional study with 947 Chinese children was conducted. A multivariable linear regression model was used to analyze the association between BMAL1 gene polymorphisms and fasting glucose level.

resultsAfter adjusting for age, sex, body mass index (BMI), physical activity, and unhealthy diet, GG genotype carriers of BMAL1 rs3789327 had higher fasting glucose than AA/GA genotype carriers (b = 0.101, SE = 0.050, P = 0.045). Adjusting for the same confounders, rs3816358 was shown to be significantly associated with fasting glucose (b = 0.060, SE = 0.028, P = 0.032). Furthermore, a significant interaction between rs3789327 and nutritional status on fasting glucose was identified (P

conclusionsBMAL1 polymorphisms were significantly associated with the fasting glucose level in children. Additionally, the observed interaction between nutritional status and BMAL1 supports promoting an optimal BMI in children genetically predisposed to higher glucose level. IMPACT: Polymorphisms in the essential circadian clock gene BMAL1 were associated with fasting blood glucose levels in children. Additionally, there was a significant interaction between nutritional status and BMAL1 affecting fasting glucose levels. BMAL1 rs3789327 was associated with fasting glucose only in overweight/obese children. This finding could bring novel insights into mechanisms by which nutritional status influences fasting glucose in children.

Indexed as

Diabetes Mellitus, Type 2AdultARNTL Transcription FactorsChildCross-Sectional StudiesFastingGlucoseHumansObesityPolymorphism, Single NucleotideARNTL Transcription FactorsBMAL1 protein, humanGlucose

Identifiers

PMID36732647
PMCPMC10382306
OpenAlexW4319005691

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.