Evidence map›Paper›PMID 36733911›Full record

ArticleFrontiers in physiology2023

G protein-coupled estrogen receptor 1 regulates renal endothelin-1 signaling system in a sex-specific manner.

Ginger L Guthrie, Rawan N Almutlaq, Sho Sugahara, Maryam K Butt, Craig R Brooks, David M Pollock, Eman Y Gohar

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Sodium intake and biological sex influence urinary endothelin-1 in salt-resistant adults: a pilot study.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ginger L GuthrieDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Rawan N AlmutlaqDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Sho SugaharaDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, United States.
Maryam K ButtDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Craig R BrooksDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, United States.
David M PollockDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Eman Y GoharDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, United States.
University of Alabama at Birmingham · USVanderbilt University Medical Center · US

Funding

Research Supplement to Promote DiversityP01HL136267 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2017 to 2021
$11.9M
The role of cyclin G1 in chronic kidney diseaseR01DK121101 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Craig Robert Brooks · 2019 to 2026
$3.7M
Sex Differences in Renal Sodium HandlingR00DK119413 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOHAR, EMAN · 2021 to 2023
$740k
Sex Differences in Renal Sodium HandlingK99DK119413 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOHAR, EMAN · 2019 to 2020
$182k
NHLBI NIH HHS P01 HL136267NIDDK NIH HHS K99 DK119413NIDDK NIH HHS R00 DK119413NIDDK NIH HHS R01 DK121101
6 · The paper itself

Abstract

Demographic studies reveal lower prevalence of hypertension among premenopausal females compared to age-matched males. The kidney plays a central role in the maintenance of sodium (Na

Indexed as

blood pressureGPR30kidney medullasex differencessodium handling

Identifiers

PMID36733911
PMCPMC9887121
OpenAlexW4316669340

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.