Trial reportInternational journal of radiation oncology, biology, physics2023
Neighborhood Deprivation and Rurality Associated With Patient-Reported Outcomes and Survival in Men With Prostate Cancer in NRG Oncology RTOG 0415.
Trial report in International journal of radiation oncology, biology, physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Residence in a rural setting is associated with lower five-year survival rates in patients that undergo spine surgery for breast cancer metastatic to the spine: A propensity matched analysis.North American Spine Society journal · 2026Article
- Neighborhood deprivation on increasing deficit accumulation in older breast cancer survivors and noncancer control individuals.Journal of the National Cancer Institute · 2026Article
- The impact of neighborhood-level disadvantage on symptoms, mood, and health-related quality of life among the primary brain tumor population.Neuro-oncology practice · 2026Article
- Article
- Rural-Urban Disparities in Cancer Care-Analyzing Routinely Collected Patient-Reported Outcomes. A Cross-Sectional Study.Cancer medicine · 2025Article
- Disparities Between Rural and Urban Patients With Prostate Cancer in Nebraska.Cancer medicine · 2025Article
- Neighborhood socioeconomic deprivation and patient-reported outcomes in symptom management trials for women with breast cancer.Breast cancer research and treatment · 2025Article
- Knowledge map of self-reported outcomes in patients with prostate cancer: a bibliometric analysis (2014-2023).Frontiers in urology · 2025Article
- Socioeconomic disadvantage and its impact on patient satisfaction at a multi-site radiation oncology center.Technical innovations & patient support in radiation oncology · 2024Article
- Association of race and area of deprivation index with prostate cancer incidence and lethality: results from a contemporary North American cohort.JNCI cancer spectrum · 2024Article
- Research Priorities of the Oncology Nursing Society: 2024-2027.Oncology nursing forum · 2024Article
- Impact of Respiratory Dust on Health: A Comparison Based on the Toxicity of PM2.5, Silica, and Nanosilica.International journal of molecular sciences · 2024Review
- Analysis of travel burden and travel support among patients treated at a comprehensive cancer center in the Southeastern United States.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Relationship between area-level socioeconomic status and health-related quality of life among cancer survivors.JNCI cancer spectrum · 2024Article
- Evaluating a Prostate Cancer Education and Navigation to Screening Program for Black Men in South Carolina, U.S.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
20 authors at 16 institutions in 2 countries.
Funding
Abstract
purposeRurality and neighborhood deprivation can contribute to poor patient-reported outcomes, which have not been systematically evaluated in patients with specific cancers in national trials. Our objective was to examine the effect of rurality and neighborhood socioeconomic and environmental deprivation on patient-reported outcomes and survival in men with prostate cancer in NRG Oncology RTOG 0415. METHODS AND MATERIALS: Data from men with prostate cancer in trial NRG Oncology RTOG 0415 were analyzed; 1,092 men were randomized to receive conventional radiation therapy or hypofractionated radiation therapy. Rurality was categorized as urban or rural. Neighborhood deprivation was assessed using the area deprivation index and air pollution indicators (nitrogen dioxide and particulate matter with a diameter less than 2.5 micrometers) via patient ZIP codes. Expanded Prostate Cancer Index Composite measured cancer-specific quality of life. The Hopkins symptom checklist measured anxiety and depression. EuroQoL-5 Dimension assessed general health.
resultsWe analyzed 751 patients in trial NRG Oncology RTOG 0415. At baseline, patients from the most deprived neighborhoods had worse bowel (P = .011), worse sexual (P = .042), and worse hormonal (P = .015) scores; patients from the most deprived areas had worse self-care (P = .04) and more pain (P = .047); and patients from rural areas had worse urinary (P = .03) and sexual (P = .003) scores versus patients from urban areas. Longitudinal analyses showed that the 25% most deprived areas (P = .004) and rural areas (P = .002) were associated with worse EuroQoL-5 Dimension visual analog scale score. Patients from urban areas (hazard ratio, 1.81; P = .033) and the 75% less-deprived neighborhoods (hazard ratio, 0.68; P = .053) showed relative decrease in risk of recurrence or death (disease-free survival).
conclusionsPatients with prostate cancer from the most deprived neighborhoods and rural areas had low quality of life at baseline, poor general health longitudinally, and worse disease-free survival. Interventions should screen populations from deprived neighborhoods and rural areas to improve patient access to supportive care services.
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