Evidence mapPaperPMID 36738984Full record

ReviewBiochimica et biophysica acta. Molecular and cell biology of lipids2023

From worms to humans: Understanding intestinal lipid metabolism via model organisms.

Darby W Kozan, Joshua T Derrick, William B Ludington, Steven A Farber

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Effects of dietary supplementation ofFrontiers in veterinary science · 2024
    Article
  9. Article
  10. Earth Worming-An Evaluation of Earthworm (Foods (Basel, Switzerland) · 2023
    Article
  11. Glycine differentially improved the growth and biochemical composition ofFrontiers in bioengineering and biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Darby W KozanDepartment of Biology, Johns Hopkins University, Baltimore, MD, United States; Department of Embryology, Carnegie Institute for Science, Baltimore, MD, United States.
Joshua T DerrickDepartment of Biology, Johns Hopkins University, Baltimore, MD, United States; Department of Embryology, Carnegie Institute for Science, Baltimore, MD, United States.
William B LudingtonDepartment of Biology, Johns Hopkins University, Baltimore, MD, United States; Department of Embryology, Carnegie Institute for Science, Baltimore, MD, United States.
Steven A FarberDepartment of Biology, Johns Hopkins University, Baltimore, MD, United States; Department of Embryology, Carnegie Institute for Science, Baltimore, MD, United States. Electronic address: farber@carnegiescience.edu.
Johns Hopkins University · USDepartment of Embryology · US

Funding

Cellular and Molecular BiologyT32GM141804 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$853k
Identifying genes required for digestive physiology and lipid metabolismR01DK093399 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$607k
NHLBI NIH HHS R01 HL158054NIDDK NIH HHS R01 DK093399NIDDK NIH HHS R01 DK116079NIDDK NIH HHS R01 DK128454NIGMS NIH HHS T32 GM141804
6 · The paper itself

Abstract

The intestine is responsible for efficient absorption and packaging of dietary lipids before they enter the circulatory system. This review provides a comprehensive overview of how intestinal enterocytes from diverse model organisms absorb dietary lipid and subsequently secrete the largest class of lipoproteins (chylomicrons) to meet the unique needs of each animal. We discuss the putative relationship between diet and metabolic disease progression, specifically Type 2 Diabetes Mellitus. Understanding the molecular response of intestinal cells to dietary lipid has the potential to undercover novel therapies to combat metabolic syndrome.

Indexed as

Diabetes Mellitus, Type 2Lipid MetabolismAnimalsDietary FatsHumansIntestinal AbsorptionIntestinesDietary FatsApolipoprotein BChylomicronDrosophilaFatty acidIntestineLipidsMetabolic diseaseModel organismZebrafish

Identifiers

PMID36738984
PMCPMC9974936
OpenAlexW4318942342

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.