Evidence map›Paper›PMID 36739181›Full record

ReviewTrends in cognitive sciences2023

Improving the study of brain-behavior relationships by revisiting basic assumptions.

Christiana Westlin, Jordan E Theriault, Yuta Katsumi, Alfonso Nieto-Castanon, Aaron Kucyi, Sebastian F Ruf, Sarah M Brown, Misha Pavel, Deniz Erdogmus, Dana H Brooks and 3 more

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Speech markers of psychological change following a psychedelic 5-MeO-DMT retreat.Journal of psychopharmacology (Oxford, England) · 2026
    Article
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  16. Task Failure in Endurance Sports: A Review.Sports medicine (Auckland, N.Z.) · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christiana WestlinDepartment of Psychology, Northeastern University, Boston, MA, USA. Electronic address: westlin.c@northeastern.edu.
Jordan E TheriaultDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yuta KatsumiDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Alfonso Nieto-CastanonDepartment of Speech, Language, and Hearing Sciences, Boston University, Boston, MA, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Aaron KucyiDepartment of Psychological and Brain Sciences, Drexel University, Philadelphia, PA, USA.
Sebastian F RufDepartment of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA.
Sarah M BrownDepartment of Computer Science and Statistics, University of Rhode Island, Kingston, RI, USA.
Misha PavelKhoury College of Computer Sciences, Northeastern University, Boston, MA, USA; Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.
Deniz ErdogmusDepartment of Electrical and Computer Engineering, Northeastern University, Boston, MA, USA.
Dana H BrooksDepartment of Electrical and Computer Engineering, Northeastern University, Boston, MA, USA.
Karen S QuigleyDepartment of Psychology, Northeastern University, Boston, MA, USA.
Susan Whitfield-GabrieliDepartment of Psychology, Northeastern University, Boston, MA, USA.
Lisa Feldman BarrettDepartment of Psychology, Northeastern University, Boston, MA, USA; A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: l.barrett@northeastern.edu.

Funding

Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related PathologyR01MH113234 · NIMH · NORTHEASTERN UNIVERSITY · PI DICKERSON, BRADFORD C, ISAACOWITZ, DEREK M · 2017 to 2021
$4.2M
Biopsychosocial Mechanisms of Successful AgingR01AG071173 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lisa Feldman Barrett, BRADFORD C DICKERSON · 2022 to 2026
$3.9M
Ovarian Effects on Intrinsic Connectivity and the Affective Enhancement of MemoryR01MH109464 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREANO, JOSEPH M, BARRETT, LISA FELDMAN · 2017 to 2021
$3.5M
NIA NIH HHS R01 AG071173NIMH NIH HHS R01 MH109464NIMH NIH HHS R01 MH113234
6 · The paper itself

Abstract

Neuroimaging research has been at the forefront of concerns regarding the failure of experimental findings to replicate. In the study of brain-behavior relationships, past failures to find replicable and robust effects have been attributed to methodological shortcomings. Methodological rigor is important, but there are other overlooked possibilities: most published studies share three foundational assumptions, often implicitly, that may be faulty. In this paper, we consider the empirical evidence from human brain imaging and the study of non-human animals that calls each foundational assumption into question. We then consider the opportunities for a robust science of brain-behavior relationships that await if scientists ground their research efforts in revised assumptions supported by current empirical evidence.

Indexed as

BrainNeuroimagingAnimalsHumansbrain-behavior relationshipscomplexitydegeneracyvariationwhole-brain modeling

Identifiers

PMID36739181
PMCPMC10012342

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.