Evidence map›Paper›PMID 36740681›Full record

ArticleBMC cardiovascular disorders2023

Admission D-dimer to lymphocyte counts ratio as a novel biomarker for predicting the in-hospital mortality in patients with acute aortic dissection.

Yansong Xu, Silei Liang, Zheng Liang, Cuiqing Huang, Yihuan Luo, Guanbiao Liang, Wei Wang

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Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yansong XuEmergency Surgery Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Silei LiangMedical Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zheng LiangEmergency Surgery Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Cuiqing HuangEmergency Surgery Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yihuan LuoEmergency Surgery Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Guanbiao LiangCardiothoracic Surgery Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Wei WangEmergency Surgery Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. weiwanggx@163.com.ORCID 0000-0003-3941-4860

Funding

National Natural Science Foundation of China 81860346
6 · The paper itself

Abstract

backgroundInflammatory factors are well-established indicators for vascular disease, but the D-dimer to lymphocyte count ratio (DLR) is not measured in routine clinical care. Screening of DLR in individuals may identify individuals at in-hopital mortality of acute aortic dissection (AD).

methodsA retrospective analysis of clinical data from 2013 to 2020 was conducted to identify which factors were related to in-hospital mortality risk of AD. Baseline clinical features, cardiovascular risk factors, and laboratory parameters were obtained from the hospital database. The end point was in-hospital mortality. Forward conditional logistic regression was performed to identify independent risk factors for AA in-hospital death. The cutoff value of the DLR should be ideally calculated by receiver operating characteristic (ROC) analysis.

resultsThe in-hospital mortality rate was 15% (48 of 320 patients). Patients with in-hospital mortality had a higher admission mean DLR level than the alive group (1740 vs. 1010, P < .05). The cutoff point of DLR was 907. The in-hospital mortality rate in the high-level DLR group was significantly higher than that in the low-level DLR group (P < .05). Univariate analysis showed that 8 of 38 factors were associated with in-hospital mortality (P < .05), including admission WBC, neutrophils, lymphocytes, neutrophils/lymphocytes (NLR), prothrombin time (PT), heart rate (HR), D-dimer, and DLR. In multivariate analysis, DLR (odds ratio [OR] 2.127, 95% CI 1.034-4.373, P = 0.040), HR (odds ratio [OR] 1.016, 95% CI 1.002-1.030, P = 0.029) and PT (odds ratio [OR] 1.231, 95% CI 1.018-1.189, P = 0.032) were determined to be independent predictors of in-hospital mortality (P < .05).

conclusionCompared with the common clinical parameters PT and HR, serum DLR level on admission is an uncommon but independent parameter that can be used to assess in-hospital mortality in patients with acute AD.

Indexed as

Aortic DissectionHospital MortalityBiomarkersFibrin Fibrinogen Degradation ProductsHumansLymphocyte CountLymphocytesNeutrophilsPrognosisRetrospective StudiesROC CurveBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DAcute aortic dissectionCount ratioD-dimerD-dimer to lymphocyteIn-hospital mortality

Identifiers

PMID36740681
PMCPMC9900915

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.