Evidence map›Paper›PMID 36745808›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models.

J Brucker Nourse, Shannon N Russell, Nathan A Moniz, Kylie Peter, Lena M Seyfarth, Madison Scott, Han-A Park, Kim A Caldwell, Guy A Caldwell

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Studying the mechanisms of neurodegeneration:Frontiers in cellular neuroscience · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

J Brucker NourseDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487.
Shannon N RussellDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487.ORCID 0000-0003-4543-8391
Nathan A MonizDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487.
Kylie PeterDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487.
Lena M SeyfarthDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487.ORCID 0000-0002-0965-2844
Madison ScottDepartment of Human Nutrition and Hospitality Management, The University of Alabama, Tuscaloosa, AL 35487.ORCID 0000-0003-4377-4893
Han-A ParkDepartment of Human Nutrition and Hospitality Management, The University of Alabama, Tuscaloosa, AL 35487.ORCID 0000-0001-5563-5255
Kim A CaldwellDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487.ORCID 0000-0003-1580-6122
Guy A CaldwellDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487.ORCID 0000-0002-8283-9090
University of Alabama · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
MECHANISMS AND MODULATORS OF RESILIENCE TO DOPAMINERGIC NEURODEGENERATIONR15NS104857 · NINDS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI CALDWELL, GUY A · 2018 to 2018
$422k
NIH HHS P40 OD010440NINDS NIH HHS R15 NS104857
6 · The paper itself

Abstract

Whole-exome sequencing of Parkinson's disease (PD) patient DNA identified single-nucleotide polymorphisms (SNPs) in the tyrosine nonreceptor kinase-2 (

Indexed as

Parkinson DiseaseAnimalsCaenorhabditis elegansDisease Models, AnimalDopamineDopaminergic NeuronsEpigenesis, GeneticNeuroprotectionOxidopamineRatsDopamineOxidopamineC. elegansdopamineneuroprotectionParkinson’s diseaseRNA

Identifiers

PMID36745808
PMCPMC9963946
OpenAlexW4319303688

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.