Metformin × body weight & composition

TrialThe lancet. Diabetes & endocrinology2023

Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial.

Denice S Feig et al.PubMed ↗Publisher ↗

What the trial testedas reported · 465 people · 2023

Range includes no effect

No clear effect on body weight & composition

+0.07−0.31 to +0.45

As reported

difference 0.07, 95% CI −0.31 to 0.45

What moved togetherboth groups pooled, not the treatment’s effect

Correlation · may be no link

No clear link with body weight & composition

−0.01−0.42 to +0.37

As reported

difference −0.01, 95% CI −0.42 to 0.37

Two numbers in the abstract

the abstract, start to end

at 24 months of age (mean difference -0.01 [95% CI -0.42 to 0.37],

[1.38] with placebo; mean difference 0.07 [95% CI -0.31 to 0.45], p=0.72)

← favours treatmentfavours comparator →
could be chance
Body weight & composition
−0.01−0.42 to 0.37
Body weight & composition
0.07−0.31 to 0.45
MetforminBody weight & composition

Metformin × body weight & compositionhelps?mixed

unlikelylikely
0.500.50 without it
← favours comparatorfavours treatment →
this papermore certainless certain
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25 papers cite it

2023
2024
2025
2026
this paperpooled ittrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 36746160