Evidence map›Paper›PMID 36746325›Full record

ArticleContemporary clinical trials2023

Study protocol for a multisite randomized controlled trial of a peer navigator intervention for emergency department patients with nonfatal opioid overdose.

Kelly M Doran, Alice E Welch, Angela Jeffers, Kelsey L Kepler, Dominique Chambless, Ethan Cowan, Ian Wittman, Angela Regina, Tingyee E Chang, Susan Parraga and 5 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04317053 (Multi-Center Randomized Controlled Trial of Relay- NYC's Nonfatal Overdose Response Program), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04317053 nacompletednot on this map

Multi-Center Randomized Controlled Trial of Relay- NYC's Nonfatal Overdose Response Program

TypeinterventionalSponsorNYU Langone HealthRan2020 to 2023Enrolled253ConditionsOpioid OverdoseArmsRELAY
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Kelly M DoranDepartment of Emergency Medicine, NYU School of Medicine, 227 East 30(th) Street, New York, NY 10016, United States; Department of Population Health, NYU School of Medicine, 180 Madison Avenue, New York, NY 10016, United States. Electronic address: kelly.doran@nyulangone.org.
Alice E WelchBureau of Alcohol and Drug Use Prevention, Care, and Treatment, Division of Mental Hygiene, New York City Department of Health and Mental Hygiene, 42-09 28(th) Street, Queens, Long Island City, NY 11101, United States.
Angela JeffersBureau of Alcohol and Drug Use Prevention, Care, and Treatment, Division of Mental Hygiene, New York City Department of Health and Mental Hygiene, 42-09 28(th) Street, Queens, Long Island City, NY 11101, United States.
Kelsey L KeplerBureau of Alcohol and Drug Use Prevention, Care, and Treatment, Division of Mental Hygiene, New York City Department of Health and Mental Hygiene, 42-09 28(th) Street, Queens, Long Island City, NY 11101, United States.
Dominique ChamblessBureau of Alcohol and Drug Use Prevention, Care, and Treatment, Division of Mental Hygiene, New York City Department of Health and Mental Hygiene, 42-09 28(th) Street, Queens, Long Island City, NY 11101, United States.
Ethan CowanDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, 281 1(st) Avenue, New York, NY 10003, United States.
Ian WittmanDepartment of Emergency Medicine, NYU School of Medicine, 227 East 30(th) Street, New York, NY 10016, United States.
Angela ReginaDepartment of Emergency Medicine, Saint Barnabas Hospital Health System, 4422 3(rd) Avenue, Bronx, NY 10457, United States.
Tingyee E ChangDepartment of Emergency Medicine, NYU School of Medicine, 227 East 30(th) Street, New York, NY 10016, United States.
Susan ParragaDepartment of Emergency Medicine, NYU School of Medicine, 227 East 30(th) Street, New York, NY 10016, United States.
Jade TapiaDepartment of Emergency Medicine, NYU School of Medicine, 227 East 30(th) Street, New York, NY 10016, United States.
Cesar DiazDepartment of Emergency Medicine, NYU School of Medicine, 227 East 30(th) Street, New York, NY 10016, United States.
Marya GwadzNYU Silver School of Social Work, 1 Washington Square North, New York, NY 10003, United States.
Charles M ClelandDepartment of Population Health, NYU School of Medicine, 180 Madison Avenue, New York, NY 10016, United States.
Jennifer McNeelyDepartment of Population Health, NYU School of Medicine, 180 Madison Avenue, New York, NY 10016, United States.
New York University · USNew York City Department of Health and Mental Hygiene · USIcahn School of Medicine at Mount Sinai · USSt. Barnabas Hospital · US

Funding

NCIPC CDC HHS R01 CE003154
6 · The paper itself

Abstract

backgroundPatients presenting to emergency departments (EDs) after a nonfatal opioid-involved overdose are at high risk for future overdose and death. Responding to this risk, the New York City (NYC) Department of Health and Mental Hygiene operates the Relay initiative, which dispatches trained peer "Wellness Advocates" to meet patients in the ED after a suspected opioid-involved overdose and follow them for up to 90 days to provide support, education, referrals to treatment, and other resources using a harm reduction framework.

methodsIn this article, we describe the protocol for a multisite randomized controlled trial of Relay. Study participants are recruited from four NYC EDs and are randomized to receive the Relay intervention or site-directed care (the control arm). Outcomes are assessed through survey questionnaires conducted at 1-, 3-, and 6-months after the baseline visit, as well as through administrative health data. The primary outcome is the number of opioid-related adverse events, including any opioid-involved overdose or any other substance use-related ED visit, in the 12 months post-baseline. Secondary and exploratory outcomes will also be analyzed, as well as hypothesized mediators and moderators of Relay program effectiveness.

conclusionWe present the protocol for a multisite randomized controlled trial of a peer-delivered OD prevention intervention in EDs. We describe how the study was designed to minimize disruption to routine ED operations, and how the study was implemented and adapted during the COVID-19 pandemic. This trial is registered with ClinicalTrials.gov [NCT04317053].

Indexed as

COVID-19Drug OverdoseOpiate OverdoseOpioid-Related DisordersAnalgesics, OpioidEmergency Service, HospitalHumansMulticenter Studies as TopicPandemicsRandomized Controlled Trials as TopicAnalgesics, OpioidAddictionEmergency careOpioid use disorderOverdosePeer interventionRandomized controlled trial

Identifiers

PMID36746325
PMCPMC10718173
OpenAlexW4319166385

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.