ArticleJournal of stroke2023
Wall Shear Stress Associated with Stroke Occurrence and Mechanisms in Middle Cerebral Artery Atherosclerosis.
Article in Journal of stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Synergistic effects of a ketogenic diet and interval exercise on vascular function in obese female undergraduate students: a randomised controlled trial demonstrating accelerated improvement.Journal of health, population, and nutrition · 2026Trial
- Atherosclerotic middle cerebral artery stenosis: adjacent arterial geometry, hemodynamics and plaque features.Japanese journal of radiology · 2026Article
- FLAIR vascular hyperintensity: association with infarction and vascular lesion burden in patients with middle cerebral artery stenosis.European radiology · 2026Article
- Combined ipsilateral peak systolic velocity and ASPECTS are associated with early neurological deterioration after endovascular thrombectomy: a prospective cohort study.BMC neurology · 2026Article
- Proximal plaque cap morphology in femoropopliteal occlusion affects the primary patency of endovascular therapy: a CT angiography cohort study.La Radiologia medica · 2026Article
- Initial diagnosis and management of acute ischemic stroke: updates and future directions.Clinical and experimental emergency medicine · 2026Article
- Chronic hindlimb ischemia exacerbates ischemic stroke by disrupting cerebral hemodynamics and glycerophospholipid metabolism in mice.Scientific reports · 2026Article
- Changes in local hemodynamic forces associated with arch branched endografts.JVS-vascular science · 2026Article
- Evaluating the role of graft angle on cerebral hemodynamics following direct cerebral bypass for moyamoya disease.PloS one · 2026Article
- Mechanism-Oriented Treatment of Early Neurologic Deterioration in Acute Ischemic Stroke.Journal of stroke · 2026Review
- Geometry and Wall Shear Stress of the Contralesional Middle Cerebral Artery Are Associated With the Burden of Cerebral Small Vessel Disease in Acute Ischemic Stroke.Journal of clinical neurology (Seoul, Korea) · 2025Article
- Vessel wall imaging of vertebrobasilar artery configurations associated with posterior circulation infarction and high-risk atherosclerotic plaques.Scientific reports · 2025Article
- Anatomical location-related hemodynamic variations are associated with atherosclerosis in the middle cerebral artery: a preliminary cross-sectional 4D flow and 3D vessel wall MRI study.Quantitative imaging in medicine and surgery · 2025Article
- Differences in plaque curvature in middle cerebral artery stenosis between acute stroke and non-acute stroke.Quantitative imaging in medicine and surgery · 2025Article
- Integrating hemodynamic analysis with traditional imaging in intracranial atherosclerotic stenosis: current status and future perspectives.Frontiers in neurology · 2025Review
- Hemodynamic analysis of non-stenotic middle cerebral artery in patients with cerebral ischemia based on 4D flow MRI.Frontiers in neuroscience · 2025Article
- Geometry of Terminal Internal Carotid Artery Bifurcation May Be Associated With Middle Cerebral Artery Plaque Ulceration: A Three-Dimensional Rotational Angiography Study.Journal of stroke · 2024Article
- Arterial Lesion Location and Outcomes of Intracranial Atherosclerotic Disease.Stroke (Hoboken, N.J.) · 2024Article
- Blood viscosity associated with stroke mechanism and early neurological deterioration in middle cerebral artery atherosclerosis.Scientific reports · 2023Article
- Associations of plaque morphology and location with Intraplaque neovascularization in the carotid artery by contrast-enhanced ultrasound imaging.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
background and purposeVarious mechanisms are involved in the etiology of stroke caused by atherosclerosis of the middle cerebral artery (MCA). Here, we compared differences in plaque nature and hemodynamic parameters according to stroke mechanism in patients with MCA atherosclerosis.
methodsConsecutive patients with asymptomatic and symptomatic MCA atherosclerosis (≥50% stenosis) were enrolled. MCA plaque characteristics (location and plaque enhancement) and wall shear stress (WSS) were measured using high-resolution vessel wall and four-dimensional flow magnetic resonance imaging, respectively, at five points (initial, upstream, minimal lumen, downstream, and terminal). These parameters were compared between patients with asymptomatic and symptomatic MCA atherosclerosis with infarctions of different mechanisms (artery-to-artery embolism vs. local branch occlusion).
resultsIn total, 110 patients (46 asymptomatic, 32 artery-to-artery embolisms, and 32 local branch occlusions) were investigated. Plaques were evenly distributed in the MCA of patients with asymptomatic MCA atherosclerosis, more commonly observed in the distal MCA of patients with artery-to-artery embolism, and in the middle MCA of patients with local branch occlusion. Maximum WSS and plaque enhancement were more prominent in the minimum lumen area of patients with asymptomatic MCA atherosclerosis or those with local branch occlusion, and were more prominent in the upstream area in those with artery-to-artery embolism. The elevated variability in the maximum WSS was related to stroke caused by artery-to-artery embolism.
conclusionStroke caused by artery-to-artery embolism was related to plaque enhancement and the highest maximum WSS at the upstream point of the plaque, and was associated with elevated variability of maximum WSS.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.