Evidence map›Paper›PMID 36747712›Full record

ArticlebioRxiv : the preprint server for biology2023

Hacking brain development to test models of sensory coding.

Maria Ahmed, Adithya E Rajagopalan, Yijie Pan, Ye Li, Donnell L Williams, Erik A Pedersen, Manav Thakral, Angelica Previero, Kari C Close, Christina P Christoforou and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Maria AhmedDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Adithya E RajagopalanHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
Yijie PanDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Ye LiDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48104, USA.
Donnell L WilliamsDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Erik A PedersenDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Manav ThakralDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Angelica PrevieroDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Kari C CloseHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
Christina P ChristoforouHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
Dawen CaiDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48104, USA.
Glenn C TurnerHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
E Josephine ClowneyDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · USHoward Hughes Medical Institute · US

Funding

An Accessible Optical Toolbox for Saturated Nanoscale Analysis of Neural ArchitectureR01MH110932 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOYDEN, EDWARD S., CAI, DAWEN · 2016 to 2019
$2.8M
Generation and manipulation of combinatorial connectivity in olfactory perceptionR01DC018032 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eleanor Josephine Clowney · 2020 to 2026
$2.7M
NIDCD NIH HHS R01 DC018032NIMH NIH HHS R01 MH110932
6 · The paper itself

Abstract

Animals can discriminate myriad sensory stimuli but can also generalize from learned experience. You can probably distinguish the favorite teas of your colleagues while still recognizing that all tea pales in comparison to coffee. Tradeoffs between detection, discrimination, and generalization are inherent at every layer of sensory processing. During development, specific quantitative parameters are wired into perceptual circuits and set the playing field on which plasticity mechanisms play out. A primary goal of systems neuroscience is to understand how material properties of a circuit define the logical operations-computations--that it makes, and what good these computations are for survival. A cardinal method in biology-and the mechanism of evolution--is to change a unit or variable within a system and ask how this affects organismal function. Here, we make use of our knowledge of developmental wiring mechanisms to modify hard-wired circuit parameters in the

Identifiers

PMID36747712
PMCPMC9900841
OpenAlexW4318189912

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.