Evidence map›Paper›PMID 36747745›Full record

ArticlebioRxiv : the preprint server for biology2023

Molecular mechanisms of coronary artery disease risk at the

Hyun-Jung Kim, Paul Cheng, Stanislao Travisano, Chad Weldy, João P Monteiro, Ramendra Kundu, Trieu Nguyen, Disha Sharma, Huitong Shi, Yi Lin and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Hyun-Jung KimDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Paul ChengDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Stanislao TravisanoDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Chad WeldyDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
João P MonteiroDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Ramendra KunduDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Trieu NguyenDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Disha SharmaDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Huitong ShiDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Yi LinResearch Center for Intelligent Computing Platforms, Zhejiang Laboratory, China 311121.
Boxiang LiuDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543.
Saptarsi HaldarAmgen Inc., 1120 Veterans Blvd, South San Francisco, CA 94080.
Simon JacksonAmgen Inc., 1120 Veterans Blvd, South San Francisco, CA 94080.
Thomas QuertermousDivision of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA; 94305.
Stanford Medicine · USAmgen (United States) · USNational University of Singapore · SG

Funding

Stanford Center for Connecting DNA Variants to Function and PhenotypeUM1HG011972 · NHGRI · STANFORD UNIVERSITY · PI JESSE M ENGREITZ, THOMAS QUERTERMOUS · 2021 to 2026
$10.5M
Causal variant association mechanisms in TCF21 binding coronary disease lociR01HL134817 · NHLBI · STANFORD UNIVERSITY · PI THOMAS QUERTERMOUS · 2017 to 2026
$6.2M
The SMAD3 signaling network in coronary artery disease riskR01HL139478 · NHLBI · STANFORD UNIVERSITY · PI THOMAS QUERTERMOUS · 2018 to 2026
$3.7M
PDGFD regulates a transcriptional network to modulate smooth muscle cell transition and coronary artery disease riskR01HL156846 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2021 to 2024
$2.7M
Identifying tobacco-genetic interactions through study of the aryl hydrocarbon receptor pathway.R01HL151535 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2021 to 2024
$2.7M
LncRNA Transcriptional Mechanisms of Coronary Artery Disease RiskR01HL145708 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2019 to 2022
$1.6M
From Locus to Function: Role of ZEB2 in Human Risk of Coronary Artery DiseaseK08HL153798 · NHLBI · STANFORD UNIVERSITY · PI CHENG, PAUL PO SHENG · 2020 to 2024
$933k
A transcriptional network which governs smooth muscle transition is mediated by causal coronary artery disease gene PDGFDF32HL160067 · NHLBI · STANFORD UNIVERSITY · PI WELDY, CHAD S · 2021 to 2022
$135k
NHGRI NIH HHS UM1 HG011972NHLBI NIH HHS F32 HL160067NHLBI NIH HHS K08 HL153798NHLBI NIH HHS L30 HL159413NHLBI NIH HHS R01 HL134817NHLBI NIH HHS R01 HL139478NHLBI NIH HHS R01 HL145708NHLBI NIH HHS R01 HL151535NHLBI NIH HHS R01 HL156846
6 · The paper itself

Abstract

Platelet derived growth factor (PDGF) signaling has been extensively studied in the context of vascular disease, but the genetics of this pathway remain to be established. Genome wide association studies (GWAS) for coronary artery disease (CAD) have identified a risk locus at 11q22.3, and we have verified with fine mapping approaches that the regulatory variant rs2019090 and

Identifiers

PMID36747745
PMCPMC9900883
OpenAlexW4318305735

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.