Evidence map›Paper›PMID 36747844›Full record

ArticlebioRxiv : the preprint server for biology2023

Multi-Omic Signatures of Sarcoidosis and Progression in Bronchoalveolar Lavage Cells.

Iain R Konigsberg, Nancy W Lin, Shu-Yi Liao, Cuining Liu, Kristyn MacPhail, Margaret M Mroz, Elizabeth Davidson, Clara I Restrepo, Sunita Sharma, Li Li and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Iain R KonigsbergDepartment of Biomedical Informatics, School of Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO.
Nancy W LinDivision of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver CO.
Shu-Yi LiaoDivision of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver CO.
Cuining LiuDepartment of Biostatistics and Bioinformatics, Colorado School of Public Health, Aurora CO.
Kristyn MacPhailDivision of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver CO.
Margaret M MrozDivision of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver CO.
Elizabeth DavidsonDepartment of Biomedical Informatics, School of Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO.
Clara I RestrepoDivision of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver CO.
Sunita SharmaDivision of Pulmonary and Critical Care Sciences, Department of Medicine, School of Medicine, University of Colorado - Anschutz Medical Campus, Aurora CO.
Li LiDivision of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver CO.
Lisa A MaierDivision of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver CO.
Ivana V YangDepartment of Biomedical Informatics, School of Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO.
National Jewish Health · USUniversity of Colorado Anschutz Medical Campus · USColorado School of Public Health · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Using Multi-Omics to Define Regulators and Drivers of Granulomatous Inflammation and Chronic Beryllium DiseaseR01ES033678 · NIEHS · NATIONAL JEWISH HEALTH · PI LISA A MAIER, Ivana V Yang · 2022 to 2026
$3.1M
Epigenetic Regulation of Immune Pathways in SarcoidosisR01HL140357 · NHLBI · NATIONAL JEWISH HEALTH · PI MAIER, LISA A, YANG, IVANA V · 2018 to 2021
$2.8M
NCATS NIH HHS UL1 TR001082NHLBI NIH HHS R01 HL140357NIEHS NIH HHS R01 ES033678
6 · The paper itself

Abstract

Introduction: Sarcoidosis is a heterogeneous, granulomatous disease that can prove difficult to diagnose, with no accurate biomarkers of disease progression. Therefore, we profiled and integrated the DNA methylome, mRNAs, and microRNAs to identify molecular changes associated with sarcoidosis and disease progression that might illuminate underlying mechanisms of disease and potential genomic biomarkers. Methods: Bronchoalveolar lavage cells from 64 sarcoidosis subjects and 16 healthy controls were used. DNA methylation was profiled on Illumina HumanMethylationEPIC arrays, mRNA by RNA-sequencing, and miRNAs by small RNA-sequencing. Linear models were fit to test for effect of diagnosis and phenotype, adjusting for age, sex, and smoking. We built a supervised multi-omics model using a subset of features from each dataset. Results: We identified 46,812 CpGs, 1,842 mRNAs, and 5 miRNAs associated with sarcoidosis versus controls and 1 mRNA, Conclusions: Leveraging the DNA methylome, transcriptome, and miRNA-sequencing in sarcoidosis BAL cells, we detected widespread molecular changes associated with disease, many which are involved in immune response. These molecules may serve as diagnostic/prognostic biomarkers and/or drug targets, although future testing will be required for confirmation.

Identifiers

PMID36747844
PMCPMC9901011
OpenAlexW4318269964

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.