Trial reportEuropean endodontic journal2023
Effect of GuttaClear on Postoperative Pain After Root Canal Retreatment: A Randomized Clinical Trial.
Trial report in European endodontic journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04326998 (Natural Gutta-percha Solvent Did Not Affect Postoperative Pain in Retreatment), which is not on this map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Natural Gutta-percha Solvent Did Not Affect Postoperative Pain in Retreatment: a Randomized Clinical Trial
Who cites it
2 citing papers in PubMed.
- Comparative efficacy of solvents in removing intratubular sealer during root canal retreatment: a CLSM and SEM study.BMC oral health · 2025Article
- Endodontic retreatment efficacy with and without solvents: A systematic review.Journal of conservative dentistry and endodonticsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate postoperative pain after non-surgical root canal retreatment with or without GuttaClear.
methodsSixty participants were randomly distributed in this non-inferiority trial into two parallel singleblinded experimental groups (Group1: non-solvent, Group2: solvent). After root canal retreatment, the participants completed questionnaires using direct (numerical rating scales) and indirect (number of analgesics taken) measurements of postoperative pain at immediate, 6, 12, 24, 48, and 72 h post-retreatment. The predisposing postoperative pain factors were recorded and analysed using Generalized Estimating Equations to identify correlated factors (α=0.05).
resultsThe pain incidence was not significantly different between the groups at any time point. The highest incidence of postoperative pain occurred immediately after retreatment (35%) and then decreased to 15% at 24 h (P<0.05). The number of participants requiring analgesics was 6.67% in the non-solvent group and 9.99% in the solvent group which were similar between the groups. Patients with a history of previous postoperative pain were 21.6-fold more likely to have postoperative pain than those without (P<0.05).
conclusionThere was no difference in postoperative pain or analgesics required after root canal retreatment with or without using GuttaClear. This study is registered in ClinicalTrial.gov (NCT04326998). (EEJ-2022-05-069).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.