Evidence map›Paper›PMID 36749986›Full record

ArticleSynapse (New York, N.Y.)2023

Abnormal [

Christopher Liang, Grace A Nguyen, Tram B Danh, Anoopraj K Sandhu, Lusine L Melkonyan, Amina U Syed, Jogeshwar Mukherjee

Open access · hybridAbstract read
In one paragraph

Article in Synapse (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Reduction in [Brain research · 2025
    Article
  2. Article
  3. [International journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christopher LiangPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, California, USA.
Grace A NguyenPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, California, USA.
Tram B DanhPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, California, USA.
Anoopraj K SandhuPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, California, USA.
Lusine L MelkonyanPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, California, USA.
Amina U SyedPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, California, USA.
Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, California, USA.
University of California, Irvine · US

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
PET Imaging agents for a4b2 Nicotinic ReceptorsRF1AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHRISTIAN, BRADLEY T, MUKHERJEE, JOGESHWAR · 2019 to 2020
$2.2M
NIA NIH HHS RF1 AG029479NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

Since cholinergic dysfunction has been implicated in Alzheimer's disease (AD), the effects of Aβ plaques on nicotinic acetylcholine receptors (nAChRs) α4β2* subtype were studied using the transgenic 5xFAD mouse model of AD. Using the PET radiotracer [

Indexed as

Alzheimer DiseaseReceptors, NicotinicAnimalsBrainDisease Models, AnimalMiceMice, Inbred C57BLMice, TransgenicNicotinePositron-Emission TomographyPositron Emission Tomography Computed TomographyPyridinesPyrrolesNicotinenifenePyridinesPyrrolesReceptors, Nicotinic[125I]IBETA[18F]FEPPA[18F]Nifene5xFAD transgenic miceAlzheimer's diseasePET/CT

Identifiers

PMID36749986
PMCPMC10148164
OpenAlexW4319461267

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.