Evidence map›Paper›PMID 36751306›Full record

ArticleNature reviews. Methods primers2022

Optical coherence tomography.

B E Bouma, J F de Boer, D Huang, I K Jang, T Yonetsu, C L Leggett, R Leitgeb, D D Sampson, M Suter, B Vakoc and 2 more

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Biomedical optics express · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Real-Time High-Resolution OCT for Imaging Retinal and Choroidal Blood Flow.Investigative ophthalmology & visual science · 2026
    Article
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

B E BoumaWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
J F de BoerDepartment of Physics and Astronomy, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
D HuangCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
I K JangHarvard Medical School, Boston, MA, USA.
T YonetsuDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University.
C L LeggettDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
R LeitgebInstitute of Medical Physics, University of Vienna, Wien, Austria.
D D SampsonSchool of Physics and School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.
M SuterHarvard Medical School, Boston, MA, USA.
B VakocWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
M VilligerWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
M WojtkowskiInstitute of Physical Chemistry and International Center for Translational Eye Research, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Jacqueline Namati · 2012 to 2026
$22.4M
NIBIB NIH HHS P41 EB015903
6 · The paper itself

Abstract

Optical coherence tomography (OCT) is a non-contact method for imaging the topological and internal microstructure of samples in three dimensions. OCT can be configured as a conventional microscope, as an ophthalmic scanner, or using endoscopes and small diameter catheters for accessing internal biological organs. In this Primer, we describe the principles underpinning the different instrument configurations that are tailored to distinct imaging applications and explain the origin of signal, based on light scattering and propagation. Although OCT has been used for imaging inanimate objects, we focus our discussion on biological and medical imaging. We examine the signal processing methods and algorithms that make OCT exquisitely sensitive to reflections as weak as just a few photons and that reveal functional information in addition to structure. Image processing, display and interpretation, which are all critical for effective biomedical imaging, are discussed in the context of specific applications. Finally, we consider image artifacts and limitations that commonly arise and reflect on future advances and opportunities.

Indexed as

Angiographydetection sensitivityElastographyFourier-domainfrequency-domaininterferometryPolarimetryresolutionspectral-domainspectrometerwavelength-swept laser

Identifiers

PMID36751306
PMCPMC9901537

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.