Evidence map›Paper›PMID 36751698›Full record

ReviewJournal of Zhejiang University. Science. B2023

Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway.

Yuzhu Xu, Pan Fan, Lei Liu, X U Xuanfei, Lele Zhang, Jiadong Wang, Yuao Tao, Xiaolong Li, Xi Li, Yuntao Wang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Zhejiang University. Science. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Application of mesenchymal stem cells in ferroptosis-related diseases.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Olig2Journal of Zhejiang University. Science. B · 2024
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yuzhu XuMedical School of Southeast University, Southeast University, Nanjing 210009, China.
Pan FanMedical School of Southeast University, Southeast University, Nanjing 210009, China.
Lei LiuMedical School of Southeast University, Southeast University, Nanjing 210009, China.
X U XuanfeiDepartment of Nuclear Medicine, Zhongda Hospital Affiliated to Southeast University, School of Medicine, Southeast University, Nanjing 210009, China.
Lele ZhangMedical School of Southeast University, Southeast University, Nanjing 210009, China.
Jiadong WangMedical School of Southeast University, Southeast University, Nanjing 210009, China.
Yuao TaoMedical School of Southeast University, Southeast University, Nanjing 210009, China.
Xiaolong LiMedical School of Southeast University, Southeast University, Nanjing 210009, China.
Xi LiMedical School of Southeast University, Southeast University, Nanjing 210009, China.
Yuntao WangMedical School of Southeast University, Southeast University, Nanjing 210009, China. wangyttodd@163.com.
Southeast University · BDZhongda Hospital Southeast University · CN

Funding

the Jiangsu Provincial Natural Science Foundation of China BK20220832
6 · The paper itself

Abstract

Ex vivo culture-amplified mesenchymal stem cells (MSCs) have been studied because of their capacity for healing tissue injury. MSC transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells, but currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation period. Hence, strategies to increase the efficacy of MSC treatment are urgently needed. Iron overload, reactive oxygen species deposition, and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs, thereby hastening cell death. Notably, oxidative stress (OS) and deficient antioxidant defense induced by iron overload can result in ferroptosis. Ferroptosis may inhibit cell survival after MSC transplantation, thereby reducing clinical efficacy. In this review, we explore the role of ferroptosis in MSC performance. Given that little research has focused on ferroptosis in transplanted MSCs, further study is urgently needed to enhance the in vivo implantation, function, and duration of MSCs.

Indexed as

FerroptosisIron OverloadMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAntioxidantsHumansAntioxidantsFerroptosisGlutathione peroxidase 4 (GPX4)Iron metabolismLipid peroxidationMesenchymal stem cells (MSCs)Oxidative stress (OS)

Identifiers

PMID36751698
PMCPMC10260286
OpenAlexW4319461675

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.