Evidence map›Paper›PMID 36752166›Full record

ArticleThe Journal of physiology2023

In silico analysis of the dynamic regulation of cardiac electrophysiology by K

Stefan Meier, Adaïa Grundland, Dobromir Dobrev, Paul G A Volders, Jordi Heijman

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024
    Review
  8. Caution: merging ion channel traffic ahead.The Journal of physiology · 2023
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 4 countries.

Stefan MeierDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine, and Life Sciences, Maastricht University and Maastricht University Medical Center+, Maastricht, The Netherlands.
Adaïa GrundlandDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine, and Life Sciences, Maastricht University and Maastricht University Medical Center+, Maastricht, The Netherlands.
Dobromir DobrevInstitute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0002-4612-117X
Paul G A VoldersDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine, and Life Sciences, Maastricht University and Maastricht University Medical Center+, Maastricht, The Netherlands.
Jordi HeijmanDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine, and Life Sciences, Maastricht University and Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0002-1418-108X
Maastricht University Medical Centre · NLBaylor College of Medicine · US

Funding

Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5M
The Role of Inflammasome in the Pathogenesis of Atrial FibrillationR01HL136389 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2017 to 2026
$5.6M
Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
Cardiac fibroblast inflammasome and atrial myopathyR01HL163277 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA · 2022 to 2025
$2.8M
NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL136389NHLBI NIH HHS R01 HL163277NIH HHS R01HL089598NIH HHS R01HL131517NIH HHS R01HL136389NIH HHS R01HL163277
6 · The paper itself

Abstract

Cardiac electrophysiology is regulated by continuous trafficking and internalization of ion channels occurring over minutes to hours. K

Indexed as

Anti-Arrhythmia AgentsHypokalemiaArrhythmias, CardiacElectrophysiologic Techniques, CardiacEther-A-Go-Go Potassium ChannelsHumansIon ChannelsMyocytes, CardiacPhenethylaminesSulfonamidesAnti-Arrhythmia AgentsdofetilideEther-A-Go-Go Potassium ChannelsIon ChannelsPhenethylaminesSulfonamidescardiac arrhythmiacardiac cellular electrophysiologycomputer modeldynamicsion-channel traffickingsimulation

Identifiers

PMID36752166
PMCPMC10313819
OpenAlexW4319461679

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.