Evidence map›Paper›PMID 36754086›Full record

ArticleNature2023

The structural basis for HIV-1 Vif antagonism of human APOBEC3G.

Yen-Li Li, Caroline A Langley, Caleigh M Azumaya, Ignacia Echeverria, Nicholas M Chesarino, Michael Emerman, Yifan Cheng, John D Gross

Open access · hybridFull text read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Fitness Landscapes of APOBEC3G Antagonism by HIV-1 Vif proteins.bioRxiv : the preprint server for biology · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Regulatory Interactions between APOBEC3B N- and C-Terminal Domains.Journal of chemical information and modeling · 2025
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yen-Li LiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Caroline A LangleyDivisions of Human Biology and Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Caleigh M AzumayaFred Hutchinson Cancer Center, Electron Microscopy Shared Resource, Seattle, WA, USA.
Ignacia EcheverriaDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.
Nicholas M ChesarinoDivisions of Human Biology and Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Michael EmermanDivisions of Human Biology and Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Yifan ChengQuantitative Bioscience Institute, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9535-0369
John D GrossDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. jdgross@cgl.ucsf.edu.ORCID http://orcid.org/0000-0002-1377-4705
Fred Hutch Cancer Center · USUniversity of California, San Francisco · USHoward Hughes Medical Institute · USQB3 · USUniversity of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Project 3U54AI170792 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$35.7M
TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
X-ray Screening and Rapid Structure DeterminationP50AI150476 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EMERMAN, MICHAEL · 2019 to 2021
$14.4M
Acquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0M
Glacios™ Cryo Transmission Electron Microscope with 200 kV XFEG opticsS10OD026881 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2019 to 2019
$1.8M
NIAID NIH HHS P30 AI027757NIAID NIH HHS P50 AI150476NIAID NIH HHS T32 AI007140NIAID NIH HHS U54 AI170792NIGMS NIH HHS T32 GM007270NIH HHS S10 OD021741NIH HHS S10 OD026881
6 · The paper itself

Abstract

The APOBEC3 (A3) proteins are host antiviral cellular proteins that hypermutate the viral genome of diverse viral families. In retroviruses, this process requires A3 packaging into viral particles

Indexed as

APOBEC-3G DeaminaseHIV-1Proteolysisvif Gene Products, Human Immunodeficiency VirusAnimalsCryoelectron MicroscopyHumansPrimatesRNAUbiquitinViral Genome PackagingAPOBEC-3G DeaminaseAPOBEC3G protein, humanRNAUbiquitinvif Gene Products, Human Immunodeficiency Virusvif protein, Human immunodeficiency virus 1

Identifiers

PMID36754086
PMCPMC10033410
OpenAlexW4319656581

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read46
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.