Evidence map›Paper›PMID 36754409›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Possible Use of Non-purine Selective Xanthine Oxidoreductase Inhibitors for Prevention of Exercise-induced Acute Kidney Injury Associated with Renal Hypouricemia.

Chiharu Aizawa, Masahiro Okabe, Daisuke Takahashi, Makoto Sagasaki, Mao Watanabe, Toshinari Fujimoto, Yuuki Yoshioka, Ai Katsuma, Ai Kimura, Daisuke Miyamoto and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Gut microbiota-mediated pain sensitization: mechanisms and therapeutic implications.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
  4. Dysuricemia.Biomedicines · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Chiharu AizawaDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Masahiro OkabeDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Daisuke TakahashiSumire Kidney Clinic, Japan.
Makoto SagasakiDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Mao WatanabeDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Toshinari FujimotoDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Yuuki YoshiokaDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Ai KatsumaDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Ai KimuraDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Daisuke MiyamotoDepartment of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, Japan.
Nana SatoDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Ken OkamotoDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Kimiyoshi IchidaDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Yoichi MiyazakiDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Jikei University School of Medicine · JPThe Jikei University Hospital · JPThe University of Tokyo · JPNippon Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise-induced acute kidney injury (EIAKI) is frequently complicated with renal hypouricemia (RHUC). In patients with RHUC, limiting anaerobic exercise can prevent EIAKI. However, it is challenging to reduce exercise intensity in athletes. We herein report a 16-year-old Japanese football player with familial RHUC with compound heterozygous mutations in urate transporter 1 (URAT1) who presented with recurrent EIAKI. As prophylaxis (hydration during exercise) could not prevent EIAKI, febuxostat was initiated. EIAKI was not observed for 16 months despite exercising intensively. Hence, non-purine-selective xanthine oxidoreductase inhibitors may decrease the incidence of EIAKI in athletes with RHUC.

Indexed as

Acute Kidney InjuryOrganic Anion TransportersAdolescentEnzyme InhibitorsHumansOrganic Cation Transport ProteinsRenal Tubular Transport, Inborn ErrorsUrinary CalculiXanthine DehydrogenaseEnzyme InhibitorsOrganic Anion TransportersOrganic Cation Transport ProteinsXanthine Dehydrogenaseathleteexercise-induced acute kidney injuryfebuxostatrenal hypouricemiaselective xanthine oxidoreductase inhibitor

Identifiers

PMID36754409
PMCPMC10569912
OpenAlexW4319336781

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.