Evidence map›Paper›PMID 36756397›Full record

ArticleRSC advances2023

Late-stage functionalization of 5-nitrofurans derivatives and their antibacterial activities.

Geshuyi Chen, Zhe Chang, Pei Yuan, Si Wang, Yongxiu Yang, Xiaolei Liang, Depeng Zhao

Abstract read
In one paragraph

Article in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Geshuyi ChenThe First Clinical Medical College, Lanzhou University Lanzhou China chengshy20@lzu.edu.cn.
Zhe ChangGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University Guangzhou China zhaodp5@mail.sysu.edu.cn.
Pei YuanThe First Clinical Medical College, Lanzhou University Lanzhou China chengshy20@lzu.edu.cn.
Si WangGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University Guangzhou China zhaodp5@mail.sysu.edu.cn.
Yongxiu YangThe First Clinical Medical College, Lanzhou University Lanzhou China chengshy20@lzu.edu.cn.ORCID https://orcid.org/0000-0002-1449-4326
Xiaolei LiangThe First Clinical Medical College, Lanzhou University Lanzhou China chengshy20@lzu.edu.cn.
Depeng ZhaoGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University Guangzhou China zhaodp5@mail.sysu.edu.cn.ORCID https://orcid.org/0000-0002-3058-9958

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Structure modification of drugs is a reliable way to optimize lead compounds, among which the most striking and direct method is late-stage functionalization (LSF). Here, we employed the Cu-catalyzed C-H LSF to modify 5-nitrofuran drugs. A series of modifications have been carried out including hydroxylation, methylation, azidination, cyanation, arylation,

Identifiers

PMID36756397
PMCPMC9853512

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.