ArticleNature communications2023
A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Neurodevelopmental traits as mechanisms linking genetic predispositions to bullying involvement.European child & adolescent psychiatry · 2026Article
- Ancestral diversity in complex disease genetics: from discovery to translation.Nature reviews. Genetics · 2026Review
- Representation in genetic studies affects inference about genetic architecture.bioRxiv : the preprint server for biology · 2026Article
- Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.Genetic epidemiology · 2026Article
- Per-allele disease and complex trait effect sizes are predominantly African MAF-dependent in European populations.medRxiv : the preprint server for health sciences · 2026Article
- MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data.Nature genetics · 2026Article
- HIGH-DIMENSIONAL STATISTICAL INFERENCE FOR LINKAGE DISEQUILIBRIUM SCORE REGRESSION AND ITS CROSS-ANCESTRY EXTENSIONS.Annals of statistics · 2025Article
- LDAK-KVIK performs fast and powerful mixed-model association analysis of quantitative and binary phenotypes.Nature genetics · 2025Article
- Revisiting the Trans-Ancestry Genetic Correlation of Refractive Error.Investigative ophthalmology & visual science · 2025Article
- Driving Global Health equity and precision medicine through African genomic data.Human molecular genetics · 2025Article
- Optimizing multi-breed joint genomic prediction issues in numerically small breeds for sex-limited trait in a loosely structured dairy cattle breeding system.Tropical animal health and production · 2025Article
- Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits.Nature genetics · 2025Article
- Integrative multi-omics analysis to gain new insights into COVID-19.Scientific reports · 2024Article
- Controlling for polygenic genetic confounding in epidemiologic association studies.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores.Human genetics · 2024Article
- Controlling for polygenic genetic confounding in epidemiologic association studies.bioRxiv : the preprint server for biology · 2024Article
- Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions.Developmental cognitive neuroscience · 2024Article
- An effective hyper-parameter can increase the prediction accuracy in a single-step genetic evaluation.Frontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cross-ancestry genetic correlation is an important parameter to understand the genetic relationship between two ancestry groups. However, existing methods cannot properly account for ancestry-specific genetic architecture, which is diverse across ancestries, producing biased estimates of cross-ancestry genetic correlation. Here, we present a method to construct a genomic relationship matrix (GRM) that can correctly account for the relationship between ancestry-specific allele frequencies and ancestry-specific allelic effects. Through comprehensive simulations, we show that the proposed method outperforms existing methods in the estimations of SNP-based heritability and cross-ancestry genetic correlation. The proposed method is further applied to anthropometric and other complex traits from the UK Biobank data across ancestry groups. For obesity, the estimated genetic correlation between African and European ancestry cohorts is significantly different from unity, suggesting that obesity is genetically heterogenous between these two ancestries.
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