ArticleFrontiers in nutrition2023
Extra cup of tea intake associated with increased risk of Alzheimer's disease: Genetic insights from Mendelian randomization.
Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Integrating Metabolomics Data, Network Pharmacology, and Molecular Docking to Investigate the Effect of Aging Times on the Functional Activity of Liupao Tea.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Article
- Predicting dementia in people with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia.NPJ science of food · 2025Article
- Association of lifestyle, dietary pattern, and liver function with cognition in older adults: findings from a cross-sectional study.Frontiers in nutrition · 2025Article
- Associations of Coffee and Tea Consumption on Neural Network Connectivity: Unveiling the Role of Genetic Factors in Alzheimer's Disease Risk.Nutrients · 2024Article
- Comparison of caffeine consumption behavior with plasma caffeine levels as exposure measures in drug-target mendelian randomization.American journal of epidemiology · 2024Article
- Trends and hotspots in tea and Alzheimer's disease research from 2014 to 2023: A bibliometric and visual analysis.Heliyon · 2024Review
- Dietary and smoking habits during the exam period and their effect on the academic achievement among Syrian medical students.BMC medical education · 2024Article
- Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies.Frontiers in neuroscience · 2024Review
- Genetically determined dietary habits and risk of Alzheimer's disease: a Mendelian randomization study.Frontiers in nutrition · 2024Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Background: Observational studies report inconclusive effects of tea consumption on the risk of Alzheimer's disease (AD), and the mechanisms are unclear. This study aims to investigate the effects of genetically predicted tea intake (cups of tea consumed per day) on AD, brain volume, and cerebral small vessel disease (CSVD) using the two-sample Mendelian randomization (MR) method. Methods: Summary statistics of tea intake were obtained from UK Biobank ( Results: In the primary MR analysis, tea intake significantly increased the risk of AD using two different methods (OR Conclusion: This study revealed a potential causal association between per extra cup of tea and an increased risk of AD. Genetically predicted tea intake was associated with a decreased brain volume of gray matter and the right hippocampus, which indicates that over-drinking tea might lead to a decline in language and memory functions. Our results shed light on a novel possible mechanism of tea intake to increase the risk of AD by reducing brain volume.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.