Evidence map›Paper›PMID 36762783›Full record

ArticleJournal of breast cancer2023

Aspirin Use Is Associated With Improved Outcomes in Inflammatory Breast Cancer Patients.

Christopher Johns, Allen Yen, Asal Rahimi, Yu-Lun Liu, Ann Marilyn Leitch, Ann Spangler, Prasanna Alluri, Chika Nwachukwu, Rachel Wooldridge, Deborah Farr and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of breast cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Christopher JohnsDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0001-7589-7279
Allen YenDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0002-8323-8617
Asal RahimiDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0002-2762-5049
Yu-Lun LiuDepartment of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0003-3541-1814
Ann Marilyn LeitchDepartment of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0001-6959-0078
Ann SpanglerDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0002-0982-1855
Prasanna AlluriDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0001-7517-9525
Chika NwachukwuDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0001-9732-9352
Rachel WooldridgeDepartment of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0003-4840-2829
Deborah FarrDepartment of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, USA.ORCID https://orcid.org/0000-0003-0571-3811
D W Nathan KimDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA. dongnathan@gmail.com.ORCID https://orcid.org/0000-0002-4450-3318
The University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInflammatory breast cancer (IBC) is the most aggressive form of breast cancer and has a high propensity for distant metastases. Our previous data suggested that aspirin (acetylsalicylic acid, ASA) use may be associated with reduced risk of distant metastases in aggressive breast cancer; however, there are no reported studies on the potential benefit of ASA use in patients with IBC.

methodsData from patients with non-metastatic IBC treated between 2000-2017 at two institutions, were reviewed. Overall survival (OS), disease-free survival (DFS), and distant metastasis-free survival (DMFS) were performed using Kaplan-Meier analysis. Univariate and multivariable logistic regression models were used to identify significant associated factors.

resultsOf 59 patients meeting the criteria for analysis and available for review, 14 ASA users were identified. ASA users demonstrated increased OS (

conclusionASA use during remission was associated with significantly improved OS and DMFS in patients with IBC. These results suggest that ASA may provide survival benefits to patients with IBC. Prospective clinical trials of ASA use in patients with high-risk IBC in remission should be considered.

Indexed as

AspirinInflammatory Breast NeoplasmsNeoplasm MetastasisSurvival

Identifiers

PMID36762783
PMCPMC9981985
OpenAlexW4319444238

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.