Evidence map›Paper›PMID 36764662›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2023

Personality as a Predictor of Disability in Multiple Sclerosis.

Isabele Jacot de Alcântara, Philippe Voruz, Gilles Allali, Chloé Fragnoli, Maria Paraskevi Antoniou, Patrice Henri Lalive, Julie Anne Péron

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Linking Personality Traits to Disability Progression in Multiple Sclerosis: A Longitudinal Analysis.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Isabele Jacot de AlcântaraClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Switzerland.
Philippe VoruzClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Switzerland.
Gilles AllaliLeenaards Memory Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Chloé FragnoliClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Switzerland.
Maria Paraskevi AntoniouClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Switzerland.
Patrice Henri LaliveNeurology Department, Geneva University Hospitals, Switzerland.
Julie Anne PéronClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Switzerland.
University of Geneva · CHUniversity Hospital of Geneva · CHUniversity of Lausanne · CH

Funding

University of Geneva
6 · The paper itself

Abstract

objectiveAs personality changes and personality disorders are frequently observed in multiple sclerosis (MS), personality may be a prognostic factor for this disease. The present study investigated the influence of personality on disability, progression, and treatment adherence in MS.

methodPersonality was assessed in 41 patients with Relapsing-Remitting MS (30 females; mean age = 42.63 years) using the NEO Personality Inventory-3rd edition. Disability was measured with the Expanded Disability Status Scale, and treatment adherence information was collected from the Swiss MS Cohort. Correlation, multiple linear and partial least square regressions were performed to examine relations between personality, disability, and treatment adherence in MS.

resultsAfter accounting for age and time since disease onset, our analysis revealed that Neuroticism (β = 0.32, p = 0.01) and its Vulnerability facet (β = 0.28, p < 0.05) predicted greater disability, whereas Extraversion (β = -0.25, p = 0.04) and its Activity facet (β = -0.23, p < 0.05) predicted milder disability. Regarding disability progression, correlational analysis revealed that it was negatively correlated with Extraversion (r = -0.44, p = 0.02) and the Feelings facet of Openness (r = -0.41, p = 0.03), but regressions failed to highlight any predictive links. No significant results could be demonstrated for treatment adherence.

conclusionsOverall, our study showed that some personality traits can impact disability in MS, indicating that these should be considered in clinical practice, as they could be used to adapt and improve patients' clinical support.

Indexed as

Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingAdultFemaleHumansNeuropsychological TestsPersonalityPersonality DisordersDisability/handicapsMultiple sclerosisPersonality and personality disorders

Identifiers

PMID36764662
PMCPMC10369360
OpenAlexW4319870649

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.