Evidence map›Paper›PMID 36765422›Full record

ArticleClinical epigenetics2023

Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis.

Maria Pia Campagna, Alexandre Xavier, Jim Stankovich, Vicki E Maltby, Mark Slee, Wei Z Yeh, Trevor Kilpatrick, Rodney J Scott, Helmut Butzkueven, Jeannette Lechner-Scott and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Maria Pia CampagnaDepartment of Neuroscience, Monash University, Melbourne, VIC, Australia. maria.campagna@monash.edu.
Alexandre XavierSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.
Jim StankovichDepartment of Neuroscience, Monash University, Melbourne, VIC, Australia.
Vicki E MaltbyHunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.
Mark SleeCollege of Medicine and Public Health, Flinders University, Adelaide, Australia.
Wei Z YehDepartment of Neuroscience, Monash University, Melbourne, VIC, Australia.
Trevor KilpatrickDepartment of Medicine, University of Melbourne, Melbourne, VIC, Australia.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.
Helmut ButzkuevenDepartment of Neuroscience, Monash University, Melbourne, VIC, Australia.
Jeannette Lechner-Scott *Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.
Rodney A Lea *Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.
Vilija G Jokubaitis *Department of Neuroscience, Monash University, Melbourne, VIC, Australia.
Alfred Health · AUHunter Medical Research Institute · AUJohn Hunter Hospital · AUMonash University · AUThe Royal Melbourne Hospital · AUFlinders University · AUQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregnancy in women with multiple sclerosis (wwMS) is associated with a reduction of long-term disability progression. The mechanism that drives this effect is unknown, but converging evidence suggests a role for epigenetic mechanisms altering immune and/or central nervous system function. In this study, we aimed to identify whole blood and immune cell-specific DNA methylation patterns associated with parity in relapse-onset MS.

resultsWe investigated the association between whole blood and immune cell-type-specific genome-wide methylation patterns and parity in 192 women with relapse-onset MS, matched for age and disease severity. The median time from last pregnancy to blood collection was 16.7 years (range = 1.5-44.4 years). We identified 2965 differentially methylated positions in whole blood, 68.5% of which were hypermethylated in parous women; together with two differentially methylated regions on Chromosomes 17 and 19 which mapped to TMC8 and ZNF577, respectively. Our findings validated 22 DMPs and 366 differentially methylated genes from existing literature on epigenetic changes associated with parity in wwMS. Differentially methylated genes in whole blood were enriched in neuronal structure and growth-related pathways. Immune cell-type-specific analysis using cell-type proportion estimates from statistical deconvolution of whole blood revealed further differential methylation in T cells specifically (four in CD4

conclusionDifferential methylation at genes related to neural plasticity offers a potential molecular mechanism driving the long-term effect of pregnancy on MS outcomes. Our results point to a potential 'CNS signature' of methylation in peripheral immune cells, as previously described in relation to MS progression, induced by parity. As the first epigenome-wide association study of parity in wwMS reported, validation studies are needed to confirm our findings.

Indexed as

DNA MethylationMultiple SclerosisCD8-Positive T-LymphocytesFemaleHumansMembrane ProteinsNeuronal PlasticityParityPregnancyMembrane ProteinsTMC8 protein, humanBirthEpigeneticsNeurodegenerationNeuroplasticityPregnancy

Identifiers

PMID36765422
PMCPMC9921068
OpenAlexW4319931038

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.