Evidence map›Paper›PMID 36765706›Full record

ReviewCancers2023

Unraveling the Complex Interconnection between Specific Inflammatory Signaling Pathways and Mechanisms Involved in HIV-Associated Colorectal Oncogenesis.

Botle Precious Damane, Thanyani Victor Mulaudzi, Sayed Shakeel Kader, Pragalathan Naidoo, Suzana D Savkovic, Zodwa Dlamini, Zilungile Lynette Mkhize-Kwitshana

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Botle Precious DamaneDepartment of Surgery, Steve Biko Academic Hospital, University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0003-3060-5572
Thanyani Victor MulaudziDepartment of Surgery, Steve Biko Academic Hospital, University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0003-4071-3905
Sayed Shakeel KaderDepartment of Surgery, University of KwaZulu Natal, Congella, Durban 4013, South Africa.
Pragalathan NaidooDepartment of Medical Microbiology, School of Laboratory Medicine & Medical Sciences, Medical School Campus, College of Health Sciences, University of KwaZulu-Natal-Natal, Durban 4041, South Africa.
Suzana D SavkovicSchool of Medicine, Department of Pathology & Laboratory Medicine, 1430 Tulane Ave., SL-79, New Orleans, LA 70112, USA.
Zodwa DlaminiSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0002-8012-3646
Zilungile Lynette Mkhize-KwitshanaDepartment of Medical Microbiology, School of Laboratory Medicine & Medical Sciences, Medical School Campus, College of Health Sciences, University of KwaZulu-Natal-Natal, Durban 4041, South Africa.ORCID 0000-0002-0373-9973
South African Medical Research Council · ZASteve Biko Hospital · ZATulane University · USUniversity of KwaZulu-Natal · ZA

Funding

Regulation of DGAT - dependent lipogenesis in colonic epithelial growthR01CA252055 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI SAVKOVIC, SUZANA D. · 2021 to 2025
$1.6M
National Research Foundation (NRF) 138139NCI NIH HHS R01 CA252055South African Medical Research Foundation 23108
6 · The paper itself

Abstract

The advancement of HIV treatment has led to increased life expectancy. However, people living with HIV (PLWH) are at a higher risk of developing colorectal cancers. Chronic inflammation has a key role in oncogenesis, affecting the initiation, promotion, transformation, and advancement of the disease. PLWH are prone to opportunistic infections that trigger inflammation. It has been documented that 15-20% of cancers are triggered by infections, and this percentage is expected to be increased in HIV co-infections. The incidence of parasitic infections such as helminths, with

Indexed as

colorectal cancerEMTepigeneticsHIVinflammasomeinflammationmetastasisNF-ĸBTLRvimentin

Identifiers

PMID36765706
PMCPMC9913377
OpenAlexW4318053014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.